TL;DR
Findings indicate that THC influences markers associated with hippocampal cell proliferation, neurogenesis, cannabinoid signaling and inflammation in female rats, and that some of these effects depend on estradiol status.
Alzheimer’s disease (AD) is an increasingly prevalent neurodegenerative disorder worldwide, with women showing a higher risk of developing the disease. The decline in steroid hormones after menopause may contribute to the increased susceptibility of women to neurodegenerative conditions. In parallel, cannabis-derived c...
There is a growing concern about developmental brain impairment following exposure to neonicotinoid pesticides. Experimentally, imidacloprid (IMI), a representative neonicotinoid pesticide, impairs postnatal hippocampal neurogenesis in rat offspring after maternal exposure. This study examined how IMI disrupts neurogen...
BACKGROUND Stress is a major determinant of psychopathology in which coping and cognitive impairment arise from abnormal glucocorticoid activity and brain derived neurotrophic factor (BDNF)-dependent neuroplasticity in the hippocampus. The endocannabinoid system modulates stress and hippocampal functioning since early...
The SIRT1/NF-κB pathway is highlighted as a key mechanism mediating the therapeutic effect of THC against depression by activating SIRT1 to suppress NF‑κB-mediated neuroinflammation and restore neurotrophic factor expressions.
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