Ferulic acid attenuates early life stress induced behavioral and neurochemical alterations via modulating HPA axis, oxidative stress, and NF-κB mediated neuroinflammation
It is demonstrated that ferulic acid attenuates the long-term behavioral and neurochemical consequences of ELS and support further investigation of its neuroprotective potential in stress-related neurobehavioral disorders.
Early life stress (ELS) significantly contributes to metabolic and psychological disorders by triggering oxidative stress and disrupting the hypothalamic–pituitary–adrenal (HPA) axis. This research examined ELS effects on redox status, along with anxiety-like behavior, in adolescent male Wistar rats, also assessing saf...
The SIRT1/NF-κB pathway is highlighted as a key mechanism mediating the therapeutic effect of THC against depression by activating SIRT1 to suppress NF‑κB-mediated neuroinflammation and restore neurotrophic factor expressions.
Tengteng Ma, Jianyu Yang, Yun Yuan et al.· Nan fang yi ke da xue xue ba...· 0 citations
Depression is a highly prevalent affective disorder, and current pharmacotherapies are often limited by suboptimal efficacy and adverse effects. Diosmetin, a dietary flavonoid, exhibits neuroprotective properties through antioxidant and anti-inflammatory mechanisms; however, its antidepressant potential remains insuffi...
Aparna Ray, Debarati Rakshit, Mohit Nema et al.· Biomedicine & pharmacotherap...· 0 citations
ZIN protects against D-galactose-induced cognitive and motor deficits by enhancing antioxidant and anti-inflammatory activity in the hippocampus and attenuate histopathological changes in the cortex and hippocampal areas of D-gal-induced brain aging rats.
A. Malayeri, Mohsen Zand, Sirous Rafiei Asl et al.· Molecular Biology Reports· 0 citations
BACKGROUND
Neuroinflammation and oxidative stress play vital roles in the pathogenesis of neurodegenerative diseases characterized by cognitive decline. Ursolic acid (UA), a natural pentacyclic triterpenoid compound with reported anti-inflammatory and antioxidant properties, has been suggested as a potential neuroprote...
Ga-Young Choi, Seohyeong Lee, A. Je et al.· Phytomedicine· 0 citations
BACKGROUND
Erucic acid (EA), a monounsaturated omega-9 fatty acid derived from Raphanus sativus L. seeds, has antioxidant and anti-inflammatory properties. This study investigated its neuroprotective effects against streptozotocin (STZ)-induced diabetes-associated cognitive dysfunction in rats.
METHODS
Male Wistar ra...
N. Sayyed, M. Afzal, Misbahudin Rafeeq et al.· Nutritional neuroscience· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.