RNA Structure and Its Function.

The RNA structural code: orchestrating gene expression and enabling precision therapies.

Computational modeling of an RNA-peptide world

It is hypothesize that the RNA world was, actually, an ‘RNA-peptide world’, in which, from the earliest stages of evolution, evolving RNA molecules interacted with short random peptides synthesized in a non-templated manner, which could drive the evolution of diverse RNA structures and activities, and eventually, of th...

RNA engineering approaches to aid high-resolution structure determination of medium- to large-sized RNAs.

High-resolution structure determination of RNA remains a major challenge due to its conformational flexibility, intrinsic heterogeneity, and susceptibility to degradation. Although RNA plays central roles in gene regulation, viral replication, and cellular homeostasis, RNA-only structures represent a small fraction of...

In silico designing of small molecules for targeting RNA: current landscape and future directions

Characterization of RNA Structure Dynamics with Trans-Factors Using Single-Molecule Optical Tweezers.

From RNA design to delivery: Computational strategies for functional RNA therapeutics

RNA therapeutics provide a revolutionary means of treating a variety of diseases by precisely regulating gene expression and protein synthesis, with great medical significance. However, there are three key challenges to its clinical application: the inherent instability of RNA, the need for controlled regulation of RNA...