The intricate crosstalk among DDR deficiency, epigenetic alterations, and inflammatory signaling constitutes a central axis in HNC pathobiology and therapeutic resistance and targeting these interconnected pathways through rational combination strategies offers a promising avenue to enhance treatment efficacy and advance precision oncology.
This review summarizes the major DDR pathways, their roles in tumor evolution and immune remodeling, and the rationale and limitations of combining DDR-targeted therapies with immunotherapy and discusses biomarker refinement, resistance mechanisms, and future strategies for translating genomic stress into durable antit...
Lung cancer management remains constrained by a fragmented understanding of the clinical implications of DNA Damage Response (DDR) pathways. This review synthesizes current evidence to position DDR alterations as potential prognostic, predictive, and therapeutic biomarkers. Prognostically, overexpression of FEN1, BRCA1...
Ana-Karla Durán-Toribio, Ignacio F Jiménez-Díaz, E. Caballé-Pérez et al.· Critical reviews in oncology...· 0 citations
This review provides a detailed overview of the epigenetic mechanisms that control ovarian cancer biology, with specific focus on their role in drug resistance and disease recurrence, and reviews the results of recent clinical trials.
Overall, epigenetic plasticity represents both a major driver of TNBC resistance and a therapeutically exploitable vulnerability, provided those future strategies account for tumor heterogeneity, adaptive cell-state transitions, biomarker-guided patient selection, and combination-based treatment design.
A. Alaa, Salma A. B. El-Din, Mohannad A. Farrag et al.· Biomedicines· 0 citations
This review integrates the major tumor-intrinsic and tumor-extrinsic mechanisms that drive ICI resistance, including defective antigen presentation, impaired interferon signaling, oncogenic and epigenetic immune escape programs, metabolic rewiring, suppressive myeloid and stromal circuits, abnormal vasculature, and pro...
R. Karataş, Yaren Alras, Sarenur Teki̇ner et al.· Immunologic research· 0 citations
Abstract Background Colorectal cancer (CRC) is a biologically diverse malignancy driven by a complex interplay of genetic mutations, epigenetic changes, tumour microenvironmental factors and host–microbial interactions. Foundational molecular events including APC-associated Wnt/β-catenin dysregulation, TP53 inactivatio...
Suvarna Bhokare, A. Wagh, P. Jadhav et al.· Biomarkers· 0 citations
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