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Open access Sep 2026

Gut microbiota-dependent phenylpropanoic acid derivatives reduced in cancer cachexia protect against myotube atrophy

Cancer cachexia is a debilitating disease characterized by muscle atrophy. Given the gut dysbiosis in cancer cachexia and the increasing evidence of a gut-muscle axis, we explored the potential beneficial effects of bacteria-dependent metabolites on myotube atrophy. Using both hypothesis-driven and hypothesis-free appr...

Alexandra L. Degraeve, Xiao-Lin Li, Camille Lefevre et al. · 0 citations
Open access Aug 2026

Mitochondrial dysfunction as a hallmark of brain senescence in telomerase-deficient mice

A major consequence of telomere dysfunction associated with pathological brain aging is the downregulation of mitochondrial activity, which contributes to the selective vulnerability of specific brain regions, highlighting mitochondrial pathways as attractive targets for interventions aimed at preserving brain health d...

Debora Palomares, Joana Jorgji, Shirine Saleki et al. · 0 citations

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