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Mitochondrial dysfunction as a hallmark of brain senescence in telomerase-deficient mice

Debora Palomares Joana Jorgji Shirine Saleki Tasha Ibrahim Esther Paître A. Loriot Marc Dieu S. Burteau Patricia Renard M. Johanns C. Corbet Laurent Gatto P. Kienlen-Campard N. Suelves
Aug 2026 · bioRxiv · 0 citations · 51 references
Biology

TL;DR

A major consequence of telomere dysfunction associated with pathological brain aging is the downregulation of mitochondrial activity, which contributes to the selective vulnerability of specific brain regions, highlighting mitochondrial pathways as attractive targets for interventions aimed at preserving brain health during aging.

DOI Semantic Scholar
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