A. Smerat

RNA vaccines in motion: A multidisciplinary exploration of design, delivery, and deployment

RNA vaccines represent a major advance in prophylactic and therapeutic vaccinology, largely due to the success of nucleoside-modified mRNA vaccines encapsulated in lipid nanoparticles (LNPs) during the COVID-19 pandemic. These platforms build on long-standing progress in RNA chemistry, immunology, and nanotechnology. T...

HTLV-1 and ATL: Decoding Molecular Pathogenesis for Next-Generation Therapies.

Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-lymphocyte malignancy arising as a late consequence of human T-cell leukemia virus type 1 (HTLV-1) infection. Despite decades of research, ATL remains characterized by a dismal prognosis and high relapse rates, representing a significant clinical challenge. This r...

Clinical significance of lncRNA-miRNA axes in ischemic stroke: Diagnostic value, prognostic relevance, and therapeutic potential.

Ischemic stroke and subsequent reperfusion injury are major causes of mortality and long-term neurological disability, driven by complex mechanisms of excitotoxicity, oxidative stress, neuroinflammation, endothelial dysfunction, and blood-brain barrier disruption. Increasing evidence indicates that long non-coding RNA...

Experimental and machine learning-assisted optimization of diesel engines using swirl-generating piston designs and operating variables

This study explores the influence of swirl-inducing piston modifications and key engine operating parameters on the performance characteristics of a diesel engine. Experiments were carried out using a single-cylinder direct injection (DI) diesel engine with a fixed compression ratio of 17.5. The investigation covered a...

Advanced cathode engineering in sodium-ion batteries: doping, phase, and interface modulation from layer oxides to polyanionics

Abstract Sodium-ion batteries (SIBs) have attracted significant attention as viable alternatives to lithium-ion batteries; however, their practical advancement remains limited by cathode-related challenges, including sluggish Na+ diffusion, structural degradation, and rapid capacity decay at high rates. This review hig...

Integrated carbon capture and utilization technologies for sustainable power systems: advances, challenges, digitalization, and future perspectives

Abstract The accelerating rise of anthropogenic CO2 emissions from fossil fuel–based power generation remains a critical challenge to achieving global climate and net-zero targets. Carbon Capture and Utilization (CCU) has emerged as a transformative pathway for simultaneously mitigating emissions, valorizing carbon res...

Multifunctional Properties of Lead-Free Vacancy-Ordered Cs2SnI6 Double Perovskite for Energy Conversion Applications

Bipolar Turiyam Graph

This article introduced Bipolar Turiyam Graphs (BTGs), detailing their defining characteristics and key parameters, and established the concept of the Bipolar Turiyam Set (BTS), and examined the significance of Bipolar Relations within these graphs.

Smart solar greenhouse heating via hybrid PTC–FPC integration: A thermo-hydraulic and exergy assessment

Meeting the growing energy demands of controlled-environment agriculture requires efficient and sustainable thermal-management solutions. This study experimentally and analytically investigates a novel hybrid solar-thermal greenhouse heating system integrating a linear parabolic trough collector, an unglazed flat-pla...

Progressive innovations in metal–organic frameworks: tailored materials, fabrication strategies, and versatile applications

Abstract Metal-organic frameworks (MOFs) and porous coordination polymers (PCPs) are types of flexible materials that consist of a metal node bonded together by organic ligands. Because of their exceptionally flexible architectures and porosity, they are useful for gas storage, catalysis, separation, drug delivery, and...

Mapping the global landscape of artificial intelligence in pancreatic cancer research

Artificial intelligence research in pancreatic cancer is growing rapidly and becoming increasingly multidisciplinary, although productivity and collaboration remain uneven.

Immobilized enzymes in continuous biotransformations: advances, challenges, and engineering perspectives for scalable biocatalytic processes.

Immobilized enzymes have become central to continuous biotransformations by enabling catalyst recovery, repeated utilization, simplified product separation, and stable long-term reactor operation. This study critically evaluates how immobilization strategies, support architectures, reactor configurations, and reaction...