A. Smerat

Immobilized enzymes in continuous biotransformations: advances, challenges, and engineering perspectives for scalable biocatalytic processes.

Immobilized enzymes have become central to continuous biotransformations by enabling catalyst recovery, repeated utilization, simplified product separation, and stable long-term reactor operation. This study critically evaluates how immobilization strategies, support architectures, reactor configurations, and reaction...

Clinical translation of mRNA-based cancer vaccines for solid tumors.

Evidence from published clinical studies and 65 registered clinical trials on mRNA-based cancer vaccines are synthesized, summarizing key molecular principles, delivery strategies, clinical translation in solid tumors, and ongoing opportunities for future therapeutic development are summarized.

Comprehensive in silico genomics analysis of global trends and host-specific emergence of aminoglycoside resistance in Staphylococcus aureus: a One-Health perspective

The global resistome is mapped to map the global resistome, quantify temporal and host-specific trends, and assess the association between genetic determinants and phenotypic resistance by analyzing over 110,000 S. aureus genomes.

Impact of Four-Dose Vaccination on the Transmission Dynamics of a Fractional-Order Malaria Model in the Context of Sub-Saharan Africa

It is emphasized that achieving high completion rates across all four vaccination doses, sustained treatment access, and integrated vector control are essential for meaningful progress toward malaria elimination in Sub- Saharan Africa.

Rural Agricultural Efficiency, Climate Sustainability, and Economic Performance: An Examination of Organic and Conventional Farming

Organic farming has emerged as a sustainable alternative to conventional farming, providing potential benefits in environmental conservation, crop quality, and market access. This study measures the impact of organic farming on agricultural productivity, resource utilisation, environmental sustainability, and trade com...

Intelligent fault diagnosis and simulation-based modelling of grid-connected photovoltaic systems under desert dust conditions

Photovoltaic (PV) power plants operating in desert environments experience continuous efficiency losses because dust accumulation gradually reduces solar radiation reaching the module surface, leading to lower energy production even under favourable weather conditions. Accurate prediction of normal operating behaviour...

Regulatory roles of pyroptosis-associated lncRnas in breast cancer progression and immune microenvironment.

Clinical translation remains limited by dependence on retrospective transcriptomic datasets, insufficient mechanistic validation, lack of standardized assays, and scarce prospective clinical evidence, but pyroptosis-associated lncRNAs represent a promising link between tumor progression and immune regulation, with cons...

Level Graph of Turiyam Graphs: Concepts and Applications

The concept of the (α, β, γ, δ)-level graph for a Turiyam graph, a novel extension of fuzzy and neutrosophic graphs that incorporates a fourth independent membership degree representing the unknown or liberal component, is investigated.

Anti-PD-1 single-chain variable fragments in cancer immunotherapy: from molecular engineering to clinical translation

Taken together, anti-PD-1 scFvs represent a modular platform for localized checkpoint inhibition and potentially improved cost-effectiveness compared with systemic antibodies.

Mechanical and thermal properties prediction and optimization of multiscale high performance hybrid biopolymer nanocomposites

Machine learning-enhanced fluorescence signal processing of carbon quantum dots for high-accuracy chemical sensing

A comprehensive analysis of ML-driven methodologies for denoising, spectral decomposition, feature extraction, and high-accuracy classification in CQD fluorescence systems shows how ML enables ultra-low-level analyte detection, interpretable photophysical modeling, and real-time intelligent sensing across chemical and...

Genetic association of immunosenescence to immune decline

This review discusses how inherited variation in cytokine-regulatory pathways may influence IL-6, TNF-α, interferon, and TGF-β signaling, thereby contributing to inflammatory set points that favor chronic immune activation and inflammaging.