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Pusat Pengembangan Pengujian Obat dan Makanan Nasional
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Degenerative diseases continue to impose a substantial global health burden with limited curative options. Neurodegenerative diseases, the principal focus of this review, are among the largest contributors to this burden. Stem cell therapies have emerged as a promising approach, offering the potential to replace lost c...
Most bioactive nutraceuticals and many oral pharmaceuticals share a common translational bottleneck: poor aqueous solubility, gastrointestinal instability, and low systemic bioavailability that blunt their clinical and nutritional benefit. Nanoencapsulation — the entrapment of a bioactive within a nanoscale lipid, poly...
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of proteins constitute a substantial and functionally critical fraction of the eukaryotic proteome. Through multivalent, low-affinity interactions encoded in their low-complexity domains (LCDs), IDPs drive liquid-liquid phase separatio...
Evidence is synthesised from a structured PubMed/MEDLINE and Scopus search covering 2017–March 2025 on placental EV biogenesis, cargo heterogeneity, immune modulation, organ‐specific pathological consequences, and translational potential as first‐trimester liquid biopsy candidates on placental extracellular vesicles.
This synthesis aims to guide formulation scientists, clinician‐scientists, and regulatory professionals in advancing the next generation of LNP‐based precision nanomedicines by linking molecular lipid design to manufacturing scalability, long‐term safety, and equitable access.
Current evidence on the pathophysiological mechanisms linking estrogen deficiency to lipid dysregulation in menopause, encompassing alterations in LDL and HDL metabolism, triglyceride accumulation, changes in lipoprotein lipase (LPL) activity, hepatic lipid accumulation, and the roles of estrogen receptor signaling in...
ABSTRACT Microplastics (MPs) and nanoplastics (NPs) have emerged as ubiquitous environmental contaminants with profound implications for human neurological health. Recent landmark findings confirm the bioaccumulation of MPs/NPs in human brain tissue—with concentrations reaching 4917 μg/g in 2024 autopsy samples and up...
Convergence of AI-assisted rational antigen design, next-generation mRNA platforms, and innovative adjuvant-delivery pairings represents a paradigm shift toward vaccinatable diseases previously considered intractable.
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