Author

Anne-Laure Mahul-Mellier

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Open access Sep 2026

Cryo-ET and Sub-Volume Analysis of Fibrillar Pathology in the Neurodegenerative Human Brain

Structural studies of amyloid fibrils extracted from brain tissue have identified disease-specific fibril polymorphs. However, the mechanisms driving distinct polymorphs remain unclear because no method currently links the cellular context, composition and ultrastructure of individual aggregates to their constituent fi...

Lukas van den Heuvel, Daniel A. Stähli, Julika Radecke et al. · bioRxiv · 0 citations

Open access Jul 2026

Modeling Parkinson’s pathology in human iPSC dopaminergic neurons uncovers key mechanisms of Lewy body formation and heterogeneity

A human isogenic induced pluripotent stem cell–derived dopaminergic neuron (iDA) model is presented that faithfully recapitulates the diverse biochemical, morphological, and ultrastructural features of LB neuropathology and provides critical insight into how different pathways to aSyn fibrillization and the complex int...

Anne-Laure Mahul-Mellier, Lukas van den Heuvel, Maxime Teixeira et al. · Science Advances · 2 citations

#protein folding Open access Aug 2026

A Site-Specific Organometallic Approach for Installing Tyrosine Phosphorylation Mimics to Decipher the Role of Phosphorylation in α-Synuclein Aggregation and Seeding.

This strategy provides a rapid, selective, and scalable way to introduce aromatic PTMs, producing homogeneous protein libraries essential for mechanistic studies, biomarker development, and exploring the therapeutic potential of targeting aSyn-phosphorylation for PD and related disorders.

Shaswati Mandal, Xiao-Yuan Lin, Anastasia V. Gemelli et al. · Journal of the American Chem... · 0 citations