Diabetes mellitus, particularly type 2 diabetes mellitus, remains a major metabolic disorder characterized by persistent hyperglycemia arising from insulin resistance, impaired insulin secretion, and progressive pancreatic β-cell dysfunction. Despite the availability of several glucose-lowering therapies, limitations a...
Rupa Mazumdar, Arvind Kumar, A. Singh et al.· Oriental Journal of Chemistr...· 0 citations
Novel multifunctional medication candidates are needed to treat Alzheimer’s disease (AD), a neurodegenerative illness with few treatments. A nitrogen-containing heterocycle, piperidine, is a popular medicinal chemistry scaffold with broad therapeutic potential. We synthesized a series of novel piperidin-1-yl-phenyl-ace...
A. Mishra, Ajeet Singh, Arvind Kumar et al.· Discover Molecules· 0 citations
Microbial siderophores play an important role in improving plant tolerance to abiotic and biotic stresses. Beyond iron acquisition, they support plant health by regulating oxidative stress, chelating toxic metals, and mediating beneficial plant–microbe interactions. This review highlights the role of siderophore-produc...
N. Akhtar, Y. Ahlawat, Anamika Singh et al.· International Journal of Mol...· 0 citations
A comprehensive overview of ZIKV pathogenesis, transmission routes, and molecular mechanisms underlying host–virus interactions is provided, with emphasis on structural and functional insights into key viral enzymes NS2B–NS3 protease and NS5 RNA-dependent RNA polymerase which serve as pivotal antiviral drug targets.
Arvind Kumar, Harpreet Singh, Sagar Varshney et al.· Chemical biology letters· 0 citations
The data suggest para-methoxy substitution improves antibacterial activity, meriting further studies on solubility enhancement, metabolic stability and in vivo validation.
Ankit Goel, K. Yadav, Tanya Jain et al.· Oriental Journal of Chemistr...· 0 citations
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