Chemotherapy-induced bone loss represents a major clinical challenge, particularly in aging populations, yet the contribution of cellular senescence to this process and its therapeutic potential remain incompletely understood. Here, we investigated the role of chemotherapy-induced cellular senescence in mediating skele...
David J. Izquierdo, Enrique Blancarte-Hernández, C. Schurman et al.· GeroScience· 0 citations
This work connects lysosomal signalling with intercellular communication and suggests a broader role for RECS1 in stress-responsive secretion, which bridges lysosomal signalling and extracellular vesicles biology, revealing a new mechanism for stress-responsive cell communication.
The results reinforce the idea that targeting protein synthesis with small molecules in patients carrying C9ORF72 mutations may result in improved cognitive capacity and reinforce the idea that targeting protein synthesis with small molecules in patients carrying ALS may result in improved cognitive capacity.
Paulina Torres, D. Becerra, José I. Astorga et al.· bioRxiv· 0 citations
How to build DDA PTM spectral libraries using various software tools, specifically Spectronaut, SpectroMine, and MSFragger are described, which were imported into Skyline for the analysis of previously published DIA succinylome data of Sirtuin-5 knocked-out vs wild-type mouse brains.
Alice Zhang, B. Schilling, J. Bons· Methods in molecular biology· 0 citations
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