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Oral administration of dibenzoylmethane (DBM) prevents cognitive decline in a C9ORF72-mediated FTD mouse model

Paulina Torres D. Becerra José I. Astorga M. Fuentealba Grant Kauwe Luis F. González Guillermo Diaz Vania Morales V. Valenzuela Cameron Wehrfritz Yani Y. Ngwala Claudia Sepúlveda-Quiñenao Samah Shah J. Bons L. Petrucelli Tara E. Tracy B. Schilling C. Hetz
Aug 2026 · bioRxiv · 0 citations
Biology

TL;DR

The results reinforce the idea that targeting protein synthesis with small molecules in patients carrying C9ORF72 mutations may result in improved cognitive capacity and reinforce the idea that targeting protein synthesis with small molecules in patients carrying ALS may result in improved cognitive capacity.

DOI Semantic Scholar
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