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J. Bons

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#gene editing Open access Sep 2026

The longevity gene APOE2 enhances pericyte function and reduces lipid droplets.

It is found that APOE2 expression supports pericyte functionality through increased lipid processing, providing mechanistic insight into the cerebrovascular protective effects of APOE2 in pericytes.

R. Kadir, J. Bons, Genesis Vega Hormazabal et al. · 0 citations
Open access Aug 2026

Oral administration of dibenzoylmethane (DBM) prevents cognitive decline in a C9ORF72-mediated FTD mouse model

The results reinforce the idea that targeting protein synthesis with small molecules in patients carrying C9ORF72 mutations may result in improved cognitive capacity and reinforce the idea that targeting protein synthesis with small molecules in patients carrying ALS may result in improved cognitive capacity.

Paulina Torres, D. Becerra, José I. Astorga et al. · 0 citations
2026

Generation of High-Quality Succinyl Spectral Libraries for Improved Proteome-Wide Succinylome Analysis Using Data-Independent Acquisition.

How to build DDA PTM spectral libraries using various software tools, specifically Spectronaut, SpectroMine, and MSFragger are described, which were imported into Skyline for the analysis of previously published DIA succinylome data of Sirtuin-5 knocked-out vs wild-type mouse brains.

Alice Zhang, B. Schilling, J. Bons · 0 citations

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