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Author

Claudio Hetz

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#gene editing Open access Sep 2026

The longevity gene APOE2 enhances pericyte function and reduces lipid droplets.

Pericytes are critical for maintaining blood-brain barrier (BBB) integrity and have emerged as key contributors to Alzheimer's disease (AD) pathogenesis. Although the apolipoprotein E2 (APOE2) allele is associated with reduced AD risk and increased longevity, its impact on pericyte function is unclear. We measured peri...

R. Kadir, J. Bons, Genesis Vega Hormazabal et al. · 0 citations
Open access Aug 2026

Oral administration of dibenzoylmethane (DBM) prevents cognitive decline in a C9ORF72-mediated FTD mouse model

The results reinforce the idea that targeting protein synthesis with small molecules in patients carrying C9ORF72 mutations may result in improved cognitive capacity and reinforce the idea that targeting protein synthesis with small molecules in patients carrying ALS may result in improved cognitive capacity.

Paulina Torres, D. Becerra, José I. Astorga et al. · 0 citations
Aug 2026

Optimized AAV to express the unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease features in mouse models

Treatment of 5xFAD mice with Proteostaser-1 improved spatial learning and synaptic plasticity, and reduced the deposition of amyloid plaques in the brain, which support the therapeutic potential of the UPR as a strategy to ameliorate AD features and sustain synaptic function.

Mei Li Díaz, Giovanni Tamburini, Diego Arriagada et al. · 0 citations

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