WD-repeat domain 5 (Wdr5), a core component of the SET1/MLL family of histone methyltransferases, is widely involved in the regulation of development, epigenetic control, transcription, and cell division. Wdr5 has been linked to neurodevelopmental disorders characterized by intellectual disability and developmental del...
Hui-Shan Wang, Wei Li, Peng-Cheng Ma et al.· Journal of Molecular Cell Bi...· 0 citations
It is shown that evolutionary changes in CCNB1IP1 expression have contributed to the enlargement and folding of the primate cortex and that a CCNB1IP1 knock-in can develop cortical folding in otherwise smooth mouse brains.
Ting Hu, Peng-Cheng Ma, Yi-Fan Kong et al.· Nature Genetics· 0 citations
The essential role of RNF220 is defined and novel molecular insights into the pathogenesis of male infertility are provided and provide novel molecular insights into the pathogenesis of male infertility.
Jing-Mei Cha, Huijuan Lin, Yingqian Xia et al.· Cell Death & Disease· 0 citations
The findings reveal that the RLIM–SLC7A11‐GSH signaling axis governs ferroptosis resistance in OL lineage cells, implicates this pathway in RLIM‐related neurodevelopmental disorders, and suggests GSH as a potential therapeutic strategy.
Yu-Wei Li, Hai-Jun Zhang, Jie-Ya Zhou et al.· Advancement of science· 0 citations
In vivo evidence is provided supporting a model in which DJ-1 deficiency can promote key PD-like phenotypes in tree shrews, potentially involving PSer129αSyn accumulation, nigral dopaminergic neuron loss, and motor dysfunction.
Hao Li, Leyi Mei, Jing-Mei Cha et al.· Cell Death & Disease· 0 citations
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