Greg de Souza

Thermodynamics and Kinetics of Dimerization-Coupled Fold Switching in the Chemokine XCL1.

Metamorphic proteins challenge the classical view of protein folding by reversibly interconverting between two distinct, stable native structures. XCL1 (lymphotactin) is a prototypical example, transitioning between a monomeric mixed- α / β chemokine fold and an alternate all- β fold that forms a stable dimer. Here we...