Early embryogenesis relies extensively on maternally deposited products until zygotic genome activation, yet the dynamics for the synthesis of new proteins in mammalian embryos remains poorly characterized. To address this, we applied pulsed stable isotope labelling by amino acids in cell culture (pSILAC) combined with...
L. Schmidt, Maico Y. Lechner, Javier Martín-González et al.· bioRxiv· 0 citations
Protein phosphorylation orchestrates cellular signaling and controls most biological processes, with its dysregulation driving diseases, notably cancer. Comprehensive, high-throughput phosphoproteomics remains limited by detection sensitivity, data completeness and computational bottlenecks, especially in low-input set...
Claire Koenig, Hayoung Cho, K. B. Emdal et al.· Nature Structural & Molecula...· 1 citation
Single-cell proteomics (SCP) holds the promise of decoding cellular heterogeneity at the functional level, yet achieving deep and reproducible proteome coverage from individual cells has remained a formidable challenge. Here, we establish a high-sensitivity, label-free SCP platform that extends current depth and repr...
I. Hendriks, Sara C. Buch-Larsen, Martin Rykær et al.· Nature Communications· 0 citations
Myocardial ischemia-reperfusion (MIR) injury drives adverse remodeling and heart failure after ST-elevation myocardial infarction (STEMI), yet no therapy directly targets the fibrotic response. Here, we developed a good manufacturing practice-compatible extracellular vesicle (EV)-enriched secretome from bone marrow mes...
Karl-Henrik Grinnemo, Ken Braesch-Andersen, Johan O. Wedin et al.· Cell Stem Cell· 1 citation
BACKGROUND
Chronic kidney disease (CKD) is characterized by proximal tubule (PT) stress, oxidative injury, and metabolic dysfunction. Human kidney single-nucleus RNA-sequencing (snRNA-seq) identified enrichment of ubiquitin-dependent protein catabolic processes in injured PT cells, suggesting activation of the ubiquiti...
Turgay Saritas, Lu Chen, Sadaf Ijaz et al.· Nephrology, Dialysis and Tra...· 0 citations
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