Author

Jae-Sung Woo

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#gene editing Sep 2026

Highly efficient base editing at PCSK9 and normal human embryo development.

DNA repair outcomes at nicks and mismatches introduced by base editors at the PCSK9 and HBG loci in human embryos are evaluated, finding that unlike Cas9-induced DNA breaks, base editor-induced lesions are efficiently repaired.

Stepan Jerabek, Chan-Ju Jung, M. Kappy et al. · Nature · 1 citation

Open access Jul 2026

The m⁶A reader YTHDF2 regulates mRNA transport and axon outgrowth in developing neurons

It is found that the ablation of Mettl14 in postmitotic neurons leads to impaired axonal projection during corticogenesis, and the authors show that m6A RNA marks recruit YTHDF2-associated transport machinery that favors transport over degradation, localizing selected mRNAs to neurites to promote cortical axon projecti...

Bonsang Koo, Ajeet Kumar, H. Hwang et al. · Nature Communications · 0 citations