Fluorinated organophosphorus compounds are highly valuable in transition‐metal catalysis and medicinal chemistry. Despite their significance, synthetic methods through catalytic hydrophosphination of β‐CF
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‐1,3‐enynes remain unexplored, particularly for divergent synthesis of structurally distinct phosphine deri...
Yong-Xin Teng, Xiao-Li Huang, Xiao-Dong Tang et al.· Chinese journal of chemistry· 0 citations
A series of combinational optimization strategies, including metabolic regulations, double protein fusion, and directed evolution of the rate-limiting enzymes, were conducted to improve the production of fluoro-aromatic polyketides, thus enhancing the titers to >200 mg/L from an initial ∼10 mg/L.
Ze-Long Mei, Jia-Xin Guo, Zhou-Tong Sun et al.· Angewandte Chemie· 0 citations
This work reports a protein engineering strategy that enables selective restoration of protein function in nitric oxide-rich environments and establishes nitric oxide-triggered chemical reactivation of proteins as a generalizable method for post-translational control of protein function.