#protein folding

Engineering inflammation-responsive proteins through nitric oxide-caged amino acids.

Wenkang Cai Jun-Hao Cui Zhiying Zeng Zequan Xiang Yuanzhe Xie Yeyu Su Yi Zuo Ying-Ze Liu Hao-Yu Wang Liying Chang Xue Wang Jing-Jing Wang Jun-An Ma Tao Liu

Aug 2026 · Nature Biomedical Engineering · 0 citations · 44 references

Medicine

TL;DR

This work reports a protein engineering strategy that enables selective restoration of protein function in nitric oxide-rich environments and establishes nitric oxide-triggered chemical reactivation of proteins as a generalizable method for post-translational control of protein function.

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Engineering inflammation-responsive proteins through nitric oxide-caged amino acids.

Similar papers

ATP-sensing DNA origami nanodevices for targeted modulation of purinergic signaling in inflammatory tissue injury

Dynamic covalent/coordinated nanonetworks with DNase-mimetic and ROS scavenging properties for acute inflammation treatment.

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