Sep 2026
Controllable gene delivery via masked adeno-associated viral vectors.
Zhi-Ying Zeng, Li-Ying Chang, Jing-Jing Wang et al.
· Nature Materials · 0 citations
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Open access
Aug 2026
A Tumor-Microenvironment-Responsive Chemically Masked IL‑2 Prodrug Potentiates PD‑1 Checkpoint Blockade and Elicits Robust Antitumor Efficacy
Interleukin-2 (IL-2) is a potent mediator of T-cell activation with significant potential for cancer immunotherapy, yet its clinical utility is severely constrained by its narrow therapeutic window. Here we report a chemically masked IL-2 prodrug (Cm-proIL2) that enables tumor-microenvironment-responsive cytokine activ...
Linzhi Tan, Yuning Yang, Ke-Rui Zhao et al.
· ACS Central Science · 0 citations
#protein folding
Aug 2026
Engineering inflammation-responsive proteins through nitric oxide-caged amino acids.
This work reports a protein engineering strategy that enables selective restoration of protein function in nitric oxide-rich environments and establishes nitric oxide-triggered chemical reactivation of proteins as a generalizable method for post-translational control of protein function.
Wenkang Cai, Jun-Hao Cui, Zhiying Zeng et al.
· Nature Biomedical Engineerin... · 0 citations