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Author

Kazuki Nakamae

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#gene editing Open access Oct 2026

tWhEEL: transcript-aware Whole-genomic Evaluation for Editing Locus

tWhEEL is a Docker-oriented pipeline for transcriptome-based protein prediction, similarity-based annotation, SpCas9 guide design, and function-level knockout feasibility assessment. It provides a Gene Ontology (GO-KFI) workflow and an SGD-centered pathway (PW-KFI) workflow. Version 1.3.5 corrects GO-KFI report labels...

Kazuki Nakamae, Hidemasa U. Bono · 0 citations
#gene editing Open access Oct 2026

Single-nucleotide genome editing uncovers the biological impact of rs16944 in the IL1B promoter

Interleukin-1β (IL-1β) exerts context-dependent effects in cancer immunity, promoting both inflammatory tumor progression and antitumor immune responses. The IL1B promoter single-nucleotide polymorphism rs16944 has been associated with poor prognosis in hepatocellular carcinoma, yet its functional impact on immune sign...

Yosuke Namba, Tsuyoshi Kobayashi, Keishi Hakoda et al. · 0 citations

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