Laura Amaya

Lineage tracing reveals asynchronous fate restriction in mouse embryos and stem cell-derived embryo models

A lineage-resolved view of embryogenesis reveals that cell identity alone predicts neither developmental ancestry nor the timing of fate restriction, and builds FateVec, an analysis framework that infers fate-bias dynamics and lineage-associated transcriptional programs from reconstructed phylogenies.

Lineage tracing reveals asynchronous fate restriction in mouse embryos and stem cell-derived embryo models

RNA delivery to the corneal endothelium using charge-altering releasable transporters

A charge-altering releasable transporter (CART) that delivers RNA selectively to the corneal endothelium, a non-regenerative cell layer whose dysfunction underlies several blinding conditions and establishes CARTs as a platform for non-viral gene delivery to the eye, with the potential to treat corneal dystrophies and...