Lineage tracing reveals asynchronous fate restriction in mouse embryos and stem cell-derived embryo models

Yun-Zheng Liu Jihye Park Laura Amaya Sergi Junyent Xiang-Kai Sun Jiabao Sean Xiao Yu-Qi Wang Hao Wang Yun-Rui Lu S. Nakagawa Sung-Eun Park Wen-Qi Hu Shi-Chen Liu Jiang-Bo Wei H. Kim Matt Thomson Cheng-Wei Ju Marianne E. Bronner Jun-Hong Choi Magdalena Zernicka-Goetz

Oct 2026 · bioRxiv · 0 citations

Biology

TL;DR

A lineage-resolved view of embryogenesis reveals that cell identity alone predicts neither developmental ancestry nor the timing of fate restriction, and builds FateVec, an analysis framework that infers fate-bias dynamics and lineage-associated transcriptional programs from reconstructed phylogenies.

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