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OpenKinetics Predictor (predictor.openkinetics.org), an open-source platform integrating thirteen kinetic parameter prediction methods accessible via one interface, is presented, finding inter-predictor agreement varies with metabolic context and data availability.
Pinal, a 16-billion-parameter foundation model that produces protein candidates from natural-language functional descriptions, supports natural language as a high-level interface for candidate generation in protein design, enabling programmable exploration with reduced reliance on manually specified structural or seque...
Taxol (paclitaxel) is a frontline anticancer drug widely applied for the treatment of breast, ovarian and lung cancers. Currently, its supply mainly relies on the semi-synthesis using baccatin III from Taxus plants. Heterologous biosynthesis of baccatin III in microorganisms offers a promising solution to alleviate glo...
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