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#protein folding Open access

Programmable design of functional proteins from natural language

Fengyuan Dai Shiyang You Yudian Zhu Yuan Gao Lihao Fu Xibin Zhou Jin Su Chentong Wang Yuliang Fan Xiaoxiao Ma Xianjun Deng Letong Yu Hui Qian Yan He Yitao Ke Chenchen Han Xing Chang Liangzhen Zheng Sheng Wang Yajie Wang Anping Zeng Shunzhi Wang Tong Si Jianming Liu Hongyuan Lu Fajie Yuan
Sep 2026 · bioRxiv · 31 citations · ⚡ 3 influential · 81 references
Biology

TL;DR

Pinal, a 16-billion-parameter foundation model that produces protein candidates from natural-language functional descriptions, supports natural language as a high-level interface for candidate generation in protein design, enabling programmable exploration with reduced reliance on manually specified structural or sequence constraints.

DOI Semantic Scholar
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