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M. G. Larimi

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#protein folding Open access Oct 2026

So similar, yet so different: α-synuclein recognition of the isoform-specific VDAC protein–lipid interface

Comparative analysis of α-synuclein interaction with three mammalian VDAC isoforms, complemented by corresponding data for VDAC2 substates and results from molecular dynamics simulations, reveals a new step in the chain of events leading to VDAC blockage.

T. Rostovtseva, Megha Rajendran, William M. Rosencrans et al. · 0 citations
Open access Aug 2026

Polymorphic structures of rapidly twisting 40-residue amyloid-β fibrils

Cryogenic electron microscopy is used to characterize the structure of rapidly twisting Aβ40 fibrils, for which the distance between apparent width minima in electron microscope images (“cross-over distances”) is approximately 25 nm, and contributes to the understanding of amyloid polymorphism, connections between morp...

M. G. Larimi, K. Thurber, R. Tycko · 0 citations

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