The medetomidine-midazolam-butorphanol mixture (MMB) is widely used for injectable anesthesia in mice but is associated with delayed induction, prolonged recovery, impaired oxygenation, and post-anesthetic hypothermia. We investigated whether substituting midazolam with remimazolam, alone or together with replacing med...
Findings show that the late phase of podocyte-driven CKD involves distributed protein-level remodelling, including an RNA-discordant increase in NR3C2 protein and a candidate plasma-protein-handling signature.
Koichi Ito, Masaki Watanabe, Koyuki Kawamoto et al.· The FEBS Journal· 0 citations
A multidomain framework is proposed that distinguishes target engagement, molecular correction, downstream pharmacodynamic responses, organ function, and whole-animal or patient-relevant benefit without assuming that effective treatments must improve every domain sequentially.