Author

S. Bezrukov

3 papers indexed here

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Open access Oct 2026

Towards VDAC pharmacology: Developing small-peptide channel inhibitors inspired by nature

The Voltage-Dependent Anion Channel (VDAC) forms a unique pathway across the mitochondrial outer membrane for small ions and water-soluble metabolites, such as ATP and ADP. Despite VDAC’s involvement in both normal regulation of respiration and in a wide variety of mitochondria-associated pathologies, there are, surpri...

T. Rostovtseva, P. Gurnev, D. Hoogerheide et al. · bioRxiv · 0 citations

#protein folding Open access Oct 2026

So similar, yet so different: α-synuclein recognition of the isoform-specific VDAC protein–lipid interface

Comparative analysis of α-synuclein interaction with three mammalian VDAC isoforms, complemented by corresponding data for VDAC2 substates and results from molecular dynamics simulations, reveals a new step in the chain of events leading to VDAC blockage.

T. Rostovtseva, Megha Rajendran, William M. Rosencrans et al. · bioRxiv · 0 citations

Open access Sep 2026

Linking cellular metabolism to mitochondrial outer membrane potential

The results demonstrate the metabolism-dependent generation of ΔΨMOM and provide strong evidence that VDAC regulation by voltage, observed in in vitro studies, is highly relevant to cell physiology.

Kaitlin Abrantes, Bethel G. Beyene, Nina A. Bautista et al. · Mitochondrion (Amsterdam. Pr... · 0 citations