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Author

Sakshi Bhatele

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2 papers indexed here

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Open access Jul 2026

Modeling immune responses to autologous and allogeneic human stem cell-derived islet grafts in vivo 2332710

Stem cell-derived β cells offer a promising strategy for Type 1 diabetes (T1D) treatment, yet the mechanisms driving immune infiltration and graft rejection remain unclear. Using human immune system (HIS) mice, we sought to compare immune responses to autologous versus allogeneic iPSC-derived islet grafts and to...

Giorgia Zanetti, Camillo Bechi Genzano, Sakshi Bhatele et al. · 0 citations
#gene editing Sep 2026

Highly efficient base editing at PCSK9 and normal human embryo development.

DNA repair outcomes at nicks and mismatches introduced by base editors at the PCSK9 and HBG loci in human embryos are evaluated, finding that unlike Cas9-induced DNA breaks, base editor-induced lesions are efficiently repaired.

Stepan Jerabek, Chan-Ju Jung, M. Kappy et al. · 1 citation

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