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Salvador Ventura

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#protein folding Open access Sep 2026

Full‐length brain‐derived α‐synuclein fibril models reveal fuzzy‐coat control of peptide recognition

A mechanistic model in which selectivity for aggregated aSyn arises from an emergent mesoscale interface combining a polyelectrolyte brush with recurrent core hotspots is presented, establishing full‐length, brain‐derived fibril ensembles as a practical framework for understanding ligand recognition at amyloid surfaces...

Carlos Pintado-Grima, Oriol Bárcenas, G. Tesei et al. · 0 citations
Review 2026

Recent cryo-EM structures redefine the functional amyloid landscape.

Cryo-EM structures of the pigment-associated amyloid PMEL have provided insight into the molecular basis of melanosome biogenesis and pigmentation, and structural studies of bacterial functional amyloids have uncovered architectures optimized for mechanical robustness and environmental resilience.

Salvador Ventura, Andrea Bartolomé-Nafría, J. García-Pardo · 0 citations

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