2026· Progress in Molecular Biology and Translational Science· Vol 223, pp.
19-39
· 0 citations
Medicine
TL;DR
Cryo-EM structures of the pigment-associated amyloid PMEL have provided insight into the molecular basis of melanosome biogenesis and pigmentation, and structural studies of bacterial functional amyloids have uncovered architectures optimized for mechanical robustness and environmental resilience.
Findings provide direct structural evidence for amyloid evolution in vivo and support a chaperone-mediated mechanism of conformer selection within a polymorphic amyloid population.
Ziang Wang, Samantha L. Weetman, Barbara Altenhuber et al.· bioRxiv· 0 citations
Amyloid fibrils are implicated in a myriad of human diseases. A striking observation is that fibrils extracted from diseased tissues are characterized by a restricted set of folds unique to the specific pathology. In contrast, fibrils grown in vitro exhibit extensive structural diversity, suggesting that specific envir...
Mikołaj I Kuska, Łucja Kozicka, S. Prodhan et al.· bioRxiv· 0 citations
The results reveal that the early amyloidogenic molten globule retains native-like secondary structure but undergoes heterogeneous structural reorganization, including simultaneous local expansion and compaction, as revealed by multisite Förster resonance energy transfer.
S. More, Prajna Mishra, S. Jha· Biochemistry· 0 citations
It is shown that the different frequency of prion fragmentation is determined by their stability, rather than the efficiency of chaperone binding, which is a key for the prion phenotype and maintenance.
A. A. Dergalev, Y. Chesnokov, A. Burtseva et al.· Nature Communications· 0 citations
Oligomeric peptides are implicated in amyloidosis, yet only a few atomic structures of amyloid oligomers have been identified. Recently, we reported an atomic structural model of human islet amylin polypeptide (hIAPP) oligomer [Shivani, S. T.; et al.Proc. Natl. Acad. Sci. U.S.A.2026, 123, e2528103123.]. The model was...
S. Shivani, Josée Maurais, Brynn E. LeMasters et al.· Journal of the American Chem...· 0 citations
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