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artificial intelligence

4,637 papers

#artificial intelligence Preprint Open access Sep 2026

FDARxBench: Benchmarking Regulatory and Clinical Reasoning on FDA Generic Drug Assessment

We introduce an expert curated, real-world benchmark for evaluating document-grounded question-answering (QA) motivated by generic drug assessment, using the U.S. Food and Drug Administration (FDA) drug label documents. Drug labels contain rich but heterogeneous clinical and regulatory information, making accurate question answering difficult for current language models. In collaboration with FDA regulatory assessors, we introduce FDARxBench, and construct a multi-stage pipeline for generating high-quality, expert curated, QA examples spanning factual, multi-hop, and refusal tasks, and design evaluation protocols to assess both open-book and closed-book reasoning. Experiments across proprietary and open-weight models reveal substantial gaps in factual grounding, long-context retrieval, and safe refusal behavior. While motivated by FDA generic drug assessment needs, this benchmark also provides a substantial foundation for challenging regulatory-grade evaluation of label comprehension. The benchmark is designed to support evaluation of LLM behavior on drug-label questions.

Betty Xiong, Jillian Fisher, Benjamin Newman et al. · 0 citations
#artificial intelligence Preprint Open access Sep 2026

ICE: Intervention-Consistent Explanation Evaluation with Statistical Grounding for LLMs

Evaluating whether explanations faithfully reflect a model's reasoning remains an open problem. Existing benchmarks use single interventions without statistical testing, making it impossible to distinguish genuine faithfulness from chance-level performance. We show that faithfulness is not a fixed property but an operator-dependent quantity that changes with the intervention method used to measure it. We introduce ICE (Intervention-Consistent Explanation), a framework that evaluates explanations against random baselines of equal size under multiple operators. Evaluating 7 LLMs across 4 tasks with deletion and retrieval infill operators, we find that switching operators crosses the positive-evidence threshold in 18% of configurations (5 of 28 attention comparisons), with gaps reaching 44 percentage points. Randomized baselines detect anti-faithfulness (explanations worse than random) in nearly one-third of English deletion configurations, invisible without random comparisons. These patterns persist across 6 non-English languages and 2 attribution methods. The methodology generalizes to step-level chain-of-thought evaluation, where preliminary results on 3 frontier models suggest that high accuracy does not imply faithful reasoning.

Abhinaba Basu, Pavan Chakraborty · 0 citations
#artificial intelligence Preprint Open access Sep 2026

FlatLands: Generative Floormap Completion From a Single Egocentric View

A single egocentric image typically captures only a small portion of the floor, yet a complete metric traversability map of the surroundings would better serve applications such as indoor navigation. We introduce FlatLands, a dataset and benchmark for single-view bird's-eye view (BEV) floor completion. The dataset contains 270,575 observations from 17,656 real metric indoor scenes drawn from six existing datasets, with aligned observation, visibility, validity, and ground-truth BEV maps, and the benchmark includes both in- and out-of-distribution evaluation protocols. We compare training-free approaches, deterministic models, ensembles, and stochastic generative models. Finally, we instantiate the task as an end-to-end monocular RGB-to-floormaps pipeline. FlatLands provides a rigorous testbed for uncertainty-aware indoor mapping and generative completion for embodied navigation.

Subhransu S. Bhattacharjee, Dylan Campbell, Rahul Shome · 0 citations
#artificial intelligence Preprint Open access Sep 2026

Shiva-DiT: Residual-Based Differentiable Top-$k$ Selection for Efficient Diffusion Transformers

Diffusion Transformers (DiTs) are costly at high resolution because self-attention scales quadratically with token sequence length. Existing pruning methods do not jointly provide end-to-end learnability, low training overhead, and deterministic token counts for predictable token-dependent computation. We propose Shiva-DiT, based on Residual-Based Differentiable Top-k Selection. Its forward pass executes hard top-k selection, while a residual-aware straight-through estimator propagates gradients to both token scores and the budget k without evaluating a second backbone path. A Context-Aware Router and Adaptive Ratio Policy learn layer- and timestep-dependent retention schedules under a target average budget. Experiments on SD3-Medium, Flux.1-dev, and PixArt-{\Sigma} show consistent reductions in FLOPs and measured latency. On SD3-Medium, Shiva-DiT provides four fidelity-latency operating points and reaches a 1.54x wall-clock speedup with competitive fidelity.

Jiaji Zhang, Hailiang Zhao, Jiaju Wu et al. · 0 citations
#artificial intelligence Preprint Open access Sep 2026

Culturally Grounded Personas in Large Language Models: Characterization and Alignment with Socio-Psychological Value Frameworks

Despite the growing utility of Large Language Models (LLMs) for simulating human behavior, the extent to which these synthetic personas accurately reflect world and moral value systems across different cultural conditionings remains uncertain. This paper investigates the alignment of synthetic, culturally-grounded personas with established frameworks, specifically the World Values Survey (WVS), the Inglehart-Welzel Cultural Map, and Moral Foundations Theory. We conceptualize and produce LLM-generated personas based on a set of interpretable WVS-derived variables, and we examine the generated personas through three complementary lenses: positioning on the Inglehart-Welzel map, which unveils their interpretation reflecting stable differences across cultural conditionings; demographic-level consistency with the World Values Survey, where response distributions broadly track human group patterns; and moral profiles derived from a Moral Foundations questionnaire, which we analyze through a culture-to-morality mapping to characterize how moral responses vary across different cultural configurations. Our approach of culturally-grounded persona generation and analysis enables evaluation of cross-cultural structure and moral variation.

Candida M. Greco, Lucio La Cava, Andrea Tagarelli · 0 citations
#artificial intelligence Preprint Open access Sep 2026

Beyond Transfer Accuracy: Mechanism-Guided Controlled Adaptation for Low-Resource Languages

Existing circuit discovery methods rely on templated tasks with clean counterfactuals, limiting their use on diverse natural text. We adapt Contextual Decomposition for Transformers (CD-T) for unstructured settings via label-balanced activation means and task-directional relevance scoring, enabling counterfactual-free circuit discovery. We leverage the discovered circuits for Circuit-Targeted Supervised Fine-Tuning (CT-SFT), restricting parameter updates to task-relevant heads and LayerNorm. Experiments on NusaX cross-lingual sentiment transfer show that CT-SFT is highly competitive for low-resource adaptation. While non-circuit sparse updates and full fine-tuning sometimes match target accuracy through capacity recruitment, CT-SFT most consistently avoids catastrophic forgetting, preserving source-language and related-task performance. Extensions to XNLI support the source-retention and intervention findings on a harder task and two model families, showing that circuit-targeted adaptation provides a more controlled, intervention-supported alternative to global fine-tuning.

Khumaisa Nur'aini, Ayu Purwarianti, Alham Fikri Aji et al. · 0 citations
#artificial intelligence Preprint Open access Sep 2026

Agent Tools Orchestration Leaks More: Dataset, Benchmark, and Mitigation

LLM agents can combine individually non-revealing tool returns and disclose a sensitive conclusion, creating Tools Orchestration Privacy Risk (TOP-R). We formalize TOP-R through three conditions: conclusion sensitivity, single-source non-inferability, and compositional inferability. We introduce Library-Grounded Reverse-Inference Seed Expansion (LRSE), a four-library reverse-construction pipeline, and use it to build TOP-Bench, a 1,000-instance benchmark evaluated under a controlled two-stage tool-use protocol. Across six LLM agents, average task completion, leakage, and H-score are 98.0 percent, 88.6 percent, and 20.4. With native reasoning enabled, four models average 81.4 percent final-response leakage and 82.4 percent reasoning-trace leakage. With reasoning disabled, three prompt-only safeguards improve H-score by an average of about 3.4 points on TOP-Bench. We further propose TOP-Align, an SFT+DPO method for learning safer task-completion boundaries. On a separate post-training evaluation set, TOP-Align improves H-score by 16.2 points over the base model, versus a 5.0-point average gain from prompt-only mitigation on the same set. These results show that TOP-R requires defenses beyond prompting alone. Dataset and code are available at https://github.com/1Ponder/TOP-R.

Yuxuan Qiao, Dongqin Liu, Hongchang Yang et al. · 0 citations
#artificial intelligence Preprint Open access Sep 2026

ContextAnyone: Context-Aware Diffusion for Character-Consistent Text-to-Video Generation

Text-to-video generation has advanced rapidly, yet preserving a character's holistic appearance from a single reference image remains challenging, particularly when the character undergoes large pose, motion, and scene changes. Existing reference-conditioned approaches primarily treat the reference image as a conditioning signal, which can weaken fine-grained appearance information as reference and noisy video tokens interact during denoising. We propose \textbf{ContextAnyone}, a context-aware diffusion framework that instead treats the reference as an explicitly preserved appearance anchor. Our key idea is to jointly reconstruct the reference image and generate the target video within a shared diffusion transformer, providing direct supervision for preserving identity and fine-grained appearance throughout denoising. To maintain the reference as a stable source of appearance information, we further introduce asymmetric information flow that allows video tokens to selectively access reference tokens while preventing noisy video features from propagating back to the reference branch. We complement this design with Gap-RoPE, which separates the positional representations of the reference and generated video tokens. Experiments on a benchmark constructed from OpenVid-HD demonstrate that ContextAnyone improves both identity and fine-grained appearance consistency over existing reference-conditioned baselines while maintaining motion characteristics close to the underlying text-to-video generator.

Ziyang Mai, Yu-Wing Tai · 0 citations
#artificial intelligence Preprint Open access Sep 2026

An Energy-Based Mechanism for Compositional Behavior

Flexible intelligence relies on the ability to reuse previously acquired behaviors and combine them differently as circumstances change. In biological and artificial systems, this ability is often attributed to gating mechanisms that determine how much each available behavior should contribute at a given time. Yet these gating rules, the dynamics that compute them, and the neural circuits that may implement them are usually introduced separately, leaving unclear whether they reflect a common underlying principle. Here, we show that they can all be derived from a single variational principle for behavioral composition. The resulting mechanism naturally gives rise to softmax gating, evolves as an energy-based dynamical system with guaranteed convergence, and admits a recurrent neural network instantiation featuring context-dependent and local interactions. Across collective behavior, human decision-making, and layered control, the same mechanism reproduces characteristic behavioral patterns, provides interpretable accounts of how different behaviors are combined, and matches or outperforms established approaches. These results provide a unified account of how behavioral composition can emerge from a common principle, with implications for understanding flexible behavior in natural systems and for designing artificial agents that can adapt by recombining existing capabilities.

Francesca Rossi, Veronica Centorrino, Francesco Bullo et al. · 0 citations
#artificial intelligence Preprint Open access Sep 2026

Inference-Time Optimization of Prompt Embeddings in Diffusion Models: A Comparison of sep-CMA-ES and Adam

Deep diffusion models have revolutionized image generation by producing high-quality outputs. However, achieving specific objectives with these models often requires costly adaptations such as fine-tuning, which can be resource-intensive and time-consuming. An alternative approach is inference-time control, which involves optimizing the prompt embeddings to guide the generation process without altering the model weights. We explore prompt-embedding search optimization for the Stable Diffusion XL Turbo model, comparing a gradient-free evolutionary approach, the Separable Covariance Matrix Adaptation Evolution Strategy (sep-CMA-ES), against the widely used gradient-based optimizer Adaptive Moment Estimation (Adam). Candidate images are evaluated by a weighted objective that combines LAION Aesthetic Predictor V2 and CLIPScore, enabling explicit trade-offs between aesthetic quality and prompt-image alignment. On 36 prompts sampled from Parti Prompts (P2) under three weight settings (aesthetics-only, balanced, alignment-only), sep-CMA-ES consistently achieves higher objective values than Adam. We additionally analyze divergence from the unoptimized baseline using cosine similarity and SSIM and report the compute and memory footprints. These results suggest that sep-CMA-ES is an effective inference-time optimizer for prompt-embedding search, improving aesthetics-alignment trade-offs and resource usage without model fine-tuning.

Dom\'icio Pereira Neto, Jo\~ao Correia, Penousal Machado · 0 citations
#artificial intelligence Preprint Open access Sep 2026

Fetch.ai: An Architecture for Modern Multi-Agent Systems

Recent surges in LLM-driven intelligent systems largely overlook decades of foundational multi-agent systems (MAS) research, resulting in frameworks with critical limitations such as centralization and inadequate trust and communication protocols. This paper introduces the Fetch.ai architecture, an industrial-strength platform designed to bridge this gap by facilitating the integration of classical MAS principles with modern AI capabilities. We present a novel, multi-layered solution built on a decentralized foundation of on-chain blockchain services for verifiable identity, discovery, and transactions. This is complemented by a comprehensive development framework for creating secure, interoperable agents, a cloud-based platform for deployment, and an intelligent orchestration layer where an agent-native LLM translates high-level human goals into complex, multi-agent workflows. We demonstrate the deployed nature of this system through a decentralized logistics use case where autonomous agents dynamically discover, negotiate, and transact with one another securely. Ultimately, the Fetch.ai stack provides a principled architecture for moving beyond current agent implementations towards open, collaborative, and economically sustainable multi-agent ecosystems.

Michael J. Wooldridge, Attila Bagoly, Jonathan J. Ward et al. · 0 citations
#artificial intelligence Preprint Open access Sep 2026

OctoPipe: Reducing Pipeline Bubbles for Heterogeneous Models via Co-Optimizing Partitioning, Placement, and Scheduling

Pipeline parallelism is widely used to train large language models (LLMs). However, increasing heterogeneity in model architectures exacerbates pipeline bubbles, thereby reducing training efficiency. Prior approaches typically optimize a single phase of the pipeline schedule (i.e., partitioning, placement, or scheduling), leaving substantial pipeline bubbles. While promising, co-optimization poses three key challenges: (1) complex performance modeling, (2) a combinatorial search space, and (3) irregular execution orders. To address these challenges, we propose OctoPipe, a pipeline parallelism system to jointly optimize partitioning, placement, and scheduling. First, we build a graph-based pipeline simulator to model heterogeneous pipeline execution for co-optimization. Second, on top of the simulator, we develop an iterative bubble-aware tuner to efficiently explore the combinatorial search space. Third, we implement a unified pipeline executor that dynamically orchestrates computation and communication to support irregular execution orders without deadlocks while maximizing communication-computation overlap. Experiments show that OctoPipe achieves 1.09--1.49$\times$ throughput improvement over the state-of-the-art pipeline parallelism approaches across various heterogeneous model configurations and GPU cluster scales.

Jihu Guo, Tenghui Ma, Wei Gao et al. · 0 citations

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