federated learning

HBA: Hijacking-Based Backdoor Attack for Vertical Federated Learning

Vertical federated learning (VFL) is a distributed machine learning paradigm designed for scenarios with vertically partitioned data features, making it highly compatible with Internet of Things (IoT) ecosystems. While promoting collaborative modeling among IoT devices, VFL also introduces new security risks, particularly backdoor attacks. Existing VFL backdoor attacks typically establish associations between triggers and target labels during the training phase by manipulating intermediate model outputs, making them easily detectable by advanced defense mechanisms. This article proposes a hijacking-based backdoor attack (HBA), which, for the first time, innovatively achieves a backdoor attack by exchanging the forward embeddings during the VFL prediction phase, without embedding traditional triggers. HBA leverages intrinsic semantic relationships in the embedding space to hijack the decision-making process of the top model during inference. HBA’s effectiveness depends on the discriminative nature of the features extracted by the bottom model, and since it does not alter the training process, it can evade most defense mechanisms based on training behavior monitoring. Experiments demonstrate that HBA achieves an attack success rate of 99.9% in classification tasks without compromising the original task’s accuracy. Furthermore, existing defense mechanisms struggle to effectively counter HBA without degrading the model’s original task performance.

RCFL: Recursive Clustered Federated Learning for Distributed Concept Drift

FedJoint: A software architecture for adaptive orchestration in federated learning systems

Privacy-Preserving Federated Multimodal Learning for Healthcare Applications

PPTRecS-FL: Privacy-preserving task recommendation strategy based on federated learning in mobile crowdsensing

FedOut: Federated learning with outsourced homomorphic encryption for resource-constrained IoT devices

ProphDR: An Interpretable Deep Learning Model for Predicting Cancer Drug Response via Multi-Omics and Cross-Attention Mechanisms.

ProphDR is an interpretable deep learning framework that integrates multiomics data and drug structural information using a hierarchical attention mechanism, and generates biologically interpretable attention maps that highlight key pharmacophores and resistance-related genes consistent with established mechanisms in NSCLC and BRCA.

Unified heterogeneity-aware benchmark of drug synergy prediction: a cross-study analysis of traditional machine learning and graph deep learning models.

The first comprehensive benchmarking framework specifically designed to accommodate inter-dataset heterogeneity is presented, finding that well-designed small datasets can match or even surpass the performance of larger benchmarks, suggesting that different metrics are applicable to different datasets/testing scenarios.

Navigating committor landscape of biomolecules with a general pairwise interaction model

A novel committor learning framework grounded in the AlphaFold 3 paradigm is proposed that elucidates how ligand substituents regulate the ratio between distinct binding pathways, offering new perspectives for structure-based drug design.

Facilitating structure-based drug discovery with an artificial intelligence-driven virtual screening platform.

The Comprehensive VS Platform with AI Engine (CVSP-AIE) for drug discovery from compound libraries integrates three AI models: KarmaDock, a fast docking model that directly updates atomic coordinates; CarsiDock, an accurate docking model that predicts protein-ligand distances and reconstructs binding poses; and RTMScore, an accurate scoring model that learns residue-atom distance distributions for affinity prediction.

An Explicit Interaction-Prompted Diffusion Framework for High-Fidelity 3D Molecular Generation.

Current structure-based drug design generative models often struggle to faithfully recapitulate genuine ligand-protein binding interactions. Instead, under the coupling of implicit learning architectures and biased training data, they tend to learn spurious statistical correlations. To address this, we propose EIP-Diff (Explicit Interaction-Prompted Diffusion), an architecture featuring a novel explicit interaction-prompt embedding mechanism that is better suited for real-world target-specific drug design. This architecture replaces biased implicit learning with explicit, residue-level biological guidance, thereby promoting more fine-grained geometric fidelity and more precise interaction-aware conditioning. To fully realize the capabilities of EIP-Diff and provide a reliable basis for performance evaluation, we further constructed CrystalData set, which provides higher-fidelity and less-biased structural supervision than existing data sets. This explicit architecture markedly improves distribution consistency: even when trained on the crossdocked data set, EIP-Diff achieves the highest alignment with authentic pharmacological distributions among evaluated models. Training on CrystalData set further enhances this alignment and improves 3D geometric accuracy, while retaining strong controllability, high chemical space coverage, and near-perfect uniqueness. In addition, target-based validation on KAT6A and YTHDC1 confirmed that EIP-Diff accurately recapitulates native-like binding modes. Furthermore, in a real-world drug design task against IDO1, we successfully designed a novel lead compound with nanomolar potency (IC50 = 0.31 nM). These results demonstrate that the EIP-Diff architecture can explicitly leverage experimentally derived structural data and biologically meaningful interaction information for target-specific molecular generation, thereby enabling its effective application to real-world structure-based drug design.

AoI Minimization in Heterogeneous MEC Networks: A Federated Learning-Assisted Hybrid DRL and Convex Approach

This paper investigates a dynamic heterogeneous mobile edge computing network (HMECN), where mobile devices (MDs) could offload their full tasks to a small base station (SBS) directly or the macro base station (MBS) in direct or relay mode. As age of information (AoI) is a comprehensive and accurate metric to capture the freshness of computation results, we formulate a long-term weighted sum AoI (LWSA) minimization problem in the HMECN by jointly optimizing the offloading decisions of MDs as well as the bandwidth and computation resource allocation of all base stations, subject to energy, delay and peak AoI constraints. To address the formulated non-convex mixed integer nonlinear programming problem, we decompose it into the offloading decision optimization (ODO) top-problem and the resource allocation optimization (RAO) sub-problem. Based on the decomposition, we propose a federated learning (FL)-assisted hybrid DRL and convex approach that is comprised of a safe multi-agent DRL algorithm, convex optimization and FL. The ODO top-problem is solved by the safe multi-agent DRL algorithm, which strictly ensures that the actions of each agent do not exceed its energy constraint and then paves the way for using convex optimization to solve the RAO sub-problem. FL is used to alleviate the training instability problem aggravated by multi-agent settings via breaking the limitation of partial knowledge for each individual agent. Simulation results demonstrate the superiority of the proposed approach in terms of the LWSA, convergence, scalability and robustness in dynamic environments.