gene editing

Stem Cells As A Promising Therapeutic Strategy For Diabetes Mellitus: A Comprehensive Review

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from impaired insulin secretion, insulin resistance, or both. Insulin and antidiabetic medications can control blood glucose levels well but cannot help recover dysfunctional pancreatic β-cells or change the pathological processe...

Polyhydroxybutyrate (PHB) production from halophiles: a comprehensive review

This review provides a comprehensive overview of recent improvements in PHB production by halophilic bacteria, covering physiological adaptations, metabolic pathways, substrate usage, fermentation techniques, and bioreactor optimisation, with particular emphasis on the use of agro-industrial residues and waste-derived...

CRISPR-Based Therapeutic Approaches in Lung Cancer

This research paper explores the potential of CRISPR-based therapeutic approaches in the diagnosis, treatment, and management of lung cancer. It examines how CRISPR-Cas genome-editing technologies can be used to identify and modify cancer-associated genes, investigate molecular mechanisms of tumor development, and deve...

Molecular Scissors With a Search Bar: A Critical Survey Review of CRISPR and the Editing of the Genome

This article presents a narrative review of CRISPR and the Editing of the Genome in the context of Biology. The literature on this topic has expanded substantially over recent decades, yet it remains fragmented across subfields, methods, and national research traditions. Drawing on an interpretive synthesis of represen...

Kcnv2 E151X Mouse Captures Hallmarks of KCNV2-Associated Retinal Dystrophy.

Kcnv2 mutant mice showed markedly reduced photopic responses and reproduced the supernormal rod phenotype described in affected individuals, and this model provides a relevant platform for mechanistic studies and preclinical evaluation of gene-based or pharmacological therapies targeting cone and rod photoreceptor dysf...

Chromosome editing Escherichia coli for efficient production of colanic acid

Genetic Basis and Molecular Breeding Strategies for Processing Quality in Chestnut (Castanea spp.)

Processing quality in chestnut (Castanea spp.) is a complex trait jointly determined by fruit development, postharvest metabolic changes, and responses to processing. However, its genetic basis and regulatory networks remain poorly understood. This review provides an integrated framework linking product-specific proces...

Xenotransplantation

OBJECTIVE: To review the current state of liver xenotransplantation and evaluate emerging strategies using genetically modified porcine organs for the management of acute liver failure. BACKGROUND: The shortage of donor organs continues to limit transplantation, with substantial waitlist mortality, especially in acute...

Divalent cation depletion enhances intrinsic neuronal excitability through CaSR-dependent modulation of threshold ion channels

It is confirmed that reducing [Ca2+]e or [Mg2+]e enhances intrinsic excitability and hyperpolarizes the AP threshold of CA1 pyramidal neurons, and that CaSR participate in the enhancement of intrinsic neuronal excitability induced by external divalent cation levels.

Target, silence, replace: a review on RNA-based drugs in modern medicine

A comprehensive overview of the several forms of RNA therapies, including small-interfering RNA, messenger RNA, and antisense-oligonucleotides (ASOs), together with information on their action mechanisms and delivery strategies that improve cellular absorption and shield RNA molecules from degradation is provided.

Cross-Model Uncertainty-Aware Minimal Editing of Cis-Regulatory Elements for Cell-Type-Selective Design

By separating search from cross-model audit and enforcing explicit edit budgets and sequence–domain safeguards, the framework provides a reproducible and auditable approach to computational CRE prioritization, regulatory-grammar studies, and synthetic regulatory-element design.

Supplementary code and analysis materials for "Reassessment of a fixed five-gene inflammatory score in cervical cancer"

This archive contains the frozen R analysis code, analysis-ready public-data derivatives, patient-level cohort audits, numerical result tables, figure-generation scripts, editable figure files, execution logs, and session information supporting the manuscript “Reassessment of a fixed five-gene inflammatory score in cer...