ABSTRACT During early embryogenesis, the sea lamprey ( Petromyzon marinus ) undergoes a dramatic form of genome reprogramming wherein specific chromosomes are selectively eliminated from somatic progenitor cells. These programmatic elimination events effectively silence all genes on these chromosomes in all somatic cel...
Kaan Ihsan I Eskut, Claire Scott, Cody Saraceno et al.· BMC Genomics· 0 citations
Activity-normalized prime editing provides a scalable framework for LDLR variant classification that substantially expands the proportion of variants with evidence for genetic diagnosis and reveals novel biology with therapeutic relevance.
P. Zhou, Minja Velimirovic, Tian Yu et al.· Circulation· 0 citations
that govern them (Hanusch et al., 2026;Ninkuu et al., 2022;Tohge et al., 2018). Recent studies compiled in this special issue collectively demonstrate that plant chemodiversity is driven by intricate coordination between regulatory networks, metabolic pathways, and environmental signals. These studies, ranging from mol...
Vincent Ninkuu, Oluwaseun Olayemi Aluko, Xiupeng Mei et al.· Frontiers in Plant Science· 0 citations
Scientific exploration is a relay race across generations. From Darwin's observations on plant movement and adaptation, to Mendel's elucidation of fundamental genetic principles using peas, to the modern molecular dissection of plant stress response mechanisms, every advance has depended not only on the strategic visio...
Enhancer editing is widely proposed as a strategy to modulate gene dosage therapeutically. EKLF/KLF1, a master erythroid transcription factor, is an attractive target because haploinsufficiency is benign and associated with hereditary persistence of fetal hemoglobin (HPFH). Here we test whether enhancer disruption can...
A. Planutis, Sanjana Pillay, Babu Mia et al.· Communications Biology· 0 citations
CUL3 is an injury-induced regulator of PT metabolic and stress-associated states and modulates antioxidant defense and mitochondrial metabolism in PT cells.
Turgay Saritas, Lu Chen, Sadaf Ijaz et al.· Nephrology, Dialysis and Tra...· 0 citations
The present investigation reports the isolation, cloning and sequence-level validation of OsbHLH024 from the salt-tolerant indica cultivar Ratnagiri-8, which constitutes a genomic resource for future comparative and functional characterisation of OsbHLH024 in salinity tolerance.
V. Shrikaran, S. Sawardekar, S. S. Sawant et al.· Journal of Advances in Biolo...· 0 citations
Genome-wide association study (GWAS) analyses have identified numerous loci associated with economic traits in cattle. Many of these loci reside in noncoding regions, and the regulatory mechanisms through which they influence complex traits remain poorly understood. Here, we integrated 657 RNA-seq libraries from 275 Hu...
Shiyuan Qiu, Li-Li Du, Bo-Yu Zhang et al.· Genomics, Proteomics & Bioin...· 0 citations
This review summarizes molecular regulatory dynamics throughout the full-life-cycle development of yak testes, highlighting core molecular networks governing spermatogonial stem-cell self-renewal, meiotic initiation, and sperm morphogenesis and further integrates the modulatory roles of the testicular microenvironment...
Qing-Qiang Yin, Xin-Xing Zheng, Xing-Dong Wang et al.· Animals· 0 citations
Eggplant, a key strategic horticultural crop within the Solanaceae family, serves as a crucial source of micronutrients, bioactive phytochemicals, and functional foods significantly contributing to food security and sustainable agriculture. Its wide agro-climatic adaptability, economic importance, and versatile culinar...
T. Chandra, Sarika Jaiswal, K. Gaurav et al.· Discover Plants· 0 citations
A CRISPR/Cas9 genome editing workflow is established for U. unicinctus based on an optimized microinjection procedure, providing a technical framework for functional genomics in echiurans and facilitating future studies of developmental mechanisms and molecular breeding in this species.
Kai Wang, Jiao Chen, Shumiao Bai et al.· Marine Biotechnology· 0 citations
Host Sowbhagya Suresh shares some of the latest news and cutting-edge research from across Microsoft—from understanding the challenges facing coding agents to uncovering how people use AI at work and improving extended-range weather forecasting. The post Microsoft Research Focus – Edition #97 appeared first on Microsoft Research.
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
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