Category
455 papers
Evaluating critically how historical nosology, molecular pathology and emerging gene-directed interventions relate to one another is evaluated, and to determine which conclusions the accessible evidence can currently sustain are evaluated.
The author did an excellent job of explaining these technologies in language that anyone could understand, and showing why they are important and relevant by giving specific examples, and I thought Wild did an excellent job of explaining these technologies in language that anyone could understand.
This study examined the complex roles of epigenetic mechanisms—DNA methylation, histone modification, chromatin remodeling, and non-coding RNAs—in enhancing stress tolerance and regulating fruit quality traits.
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It is indicated that banana DMR6 functions as a negative regulator of plant immunity and is closely associated with susceptibility to Fusarium wilt, providing a molecular basis for future functional validation and support DMR6 as a potential target for precise genome editing to develop resistant banana cultivars.
SunTag-NOVA robustly installed DNA methylation and repressed transcription at the endogenous FWA, FT and TMM genes with minimal genome-wide off-target consequences, and establishes SunTag-NOVA as a specific epigenome-editing platform for plants.
It is shown that Cedar virus does use mRNA editing, but at an unusual sequence and by inserting either an adenine or a guanine nucleotide and generating a previously unknown protein, termed U, that shares selected features with the V and W proteins of other henipaviruses.
A substantial increase in the global burden of CVDs is demonstrated, with prevalence nearly doubling between 1990 and 2019 and mortality continuing to rise worldwide.
A prioritized roadmap for integrating AI into early clinical xenotransplantation is presented, based on clinical need, data availability, technical readiness, feasibility of clinician‐supervised implementation, and potential impact on graft assessment and safety monitoring.
A structured translational roadmap is proposed that prioritizes biologically predictive design, fit-for-purpose safety assessment, scalable good manufacturing practice production, early regulatory alignment, and clinically meaningful benefit over unnecessary structural complexity.
This review highlights how neurotropic viruses co-opt epigenetic pathways to drive neurodegeneration and explores biomarker-driven strategies for personalized interventions in neurodegenerative disorders thus emphasizing potential epigenetic editing tools to restore neuronal homeostasis.
Results suggest that MDM2 3’UTR elongation may trigger a non-canonical regulatory mechanism that bypasses the traditional MDM2-p53 interaction, and suggests that APA-mediated gene modulation can induce unforeseen compensatory survival pathways in cancer cells, necessitating further investigation into the broader functional landscape of elongated 3'UTRs.
General Science
General Science
MIT affiliates engage with the MIT-IBM Computing Research Lab to bring rigorous theory to production systems.
Gemini Omni 1.1 Flash brings a new suite of creative controls and generative video capabilities to developers.
Human-Computer Interaction and Visualization
A new algorithm learns to anticipate the unprecedented scenarios that critical infrastructure and global supply chains are least prepared for.
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