Evidence is provided suggesting that StFKF1 influences the timing of flowering and tuber initiation, as well as the expression patterns of key regulatory genes, under long-day conditions, thereby contributing to a theoretical foundation for understanding developmental transitions in this specific environmental context.
Zefeng Zhai, Yongguang Liu, Haicai Li et al.· Molecular breeding· 0 citations
A new protoplast-based platform enables transient transformation and proof-of-concept CRISPR/Cas12a-mediated genome editing in European beech, a key but recalcitrant forest tree species.
Virginia Zahn, Alice-Jeannine Sievers, B. Kersten et al.· Communications Biology· 0 citations
A potential combination between gene therapy approaches and existing modulators to improve treatment eligibility, safety, and efficacy for cystic fibrosis patients is discussed.
A review of studies in which the creation of a CRISPR-Cas9 animal model has been used to find genetic drivers and develop therapies across 4 CVD domains shows the vast range of gene editing applications and the value of models that parallel human genetic pathophysiology for specific disease processes.
J. Longmire, Harrison Smith-Jaoudi, Eesha Balar et al.· Georgetown Medical Review· 0 citations
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It is demonstrated that viperin plays a central role in coordinating antiviral responses in rainbow trout macrophages and is essential for proper activation of classical IFN–ISG pathways.
Mariana Vaz, A. Florea, G. E. Themudo et al.· Scientific Reports· 0 citations
Preliminary evidence indicates that targeted editing of OsASY offers a promising strategy to reduce grain Cd content without adversely affecting major agronomic traits or yield, highlighting its potential as a molecular target for breeding low-Cd-accumulating rice varieties.
C. Tu, Wei Huang, Daobo Wang et al.· Journal of Hazardous Materia...· 0 citations
By explaining how a single amino acid change produces a hypomorphic PIEZO2 allele, the findings broaden the clinical spectrum of PIEZO2 disorders and offer structural insight into mechanotransduction.
Alec R. Nickolls, Eric M. Mulhall, Daniel J. Orlin et al.· Neuron· 0 citations
Overall, the existing findings support TAAR1 as a therapeutic target for treatment of substance use disorders, however, translating these findings into effective human pharmacotherapies requires navigating ligand-specific effects and pharmacokinetic demands and defining the role of human TAAR1 genetic diversity in therapeutic response.
Samantha M. Rios, Shkelzen Shabani, T. J. Phillips· Handbook of Experimental Pha...· 0 citations
This paper focuses on the heterologous expression of functional genes via transgenic technology and explores the potential of gene editing technologies for heavy metal remediation, thereby offering a reference for future environmental remediation efforts and the development of related processes.
Kaiyang Zheng, Yeting Weng, Ran Zhao· Sheng wu gong cheng xue bao...· 0 citations
Millets are a diverse group of underutilized C4 cereals with high photosynthetic efficiency and resilience to marginal environments; however, the functional and nutritional potential of their starches remains largely untapped. This review provided a systematic summary of current research in millet starches, covering extraction methods, multiscale structural features, physicochemical properties, modification strategies, and the genetic basis of starch biosynthesis. The main findings revealed that millet starches exhibited pronounced inter‑ and intraspecies diversity in structure and physicochemical properties, with amylose content ranging from 0.9% to 39% and relative crystallinity from 14.5% to 69%, thereby offering a broad spectrum of textural and nutritional functions. Chemical, physical, and enzymatic modifications each offered distinct advantages for tailoring starch structure, pasting behavior, thermal stability, and digestibility, and combined approaches enabled synergistic functional enhancement. Meanwhile, genetic and breeding strategies provided complementary routes for structural and functional improvement. Despite progress, significant gaps persisted regarding the specific genes, allelic variants, and regulatory networks controlling starch biosynthesis and functional diversity in millets. Future efforts should integrate standardized analytical methodologies, predictive structure-function modeling, green modification technologies, and genome‑editing platforms to unlock the full potential of millet starches as versatile, eco‑friendly, and health‑promoting ingredients.
Raheela Amin, Huabing Lu, Jing Yu et al.· Comprehensive Reviews in Foo...· 0 citations
Rice is one of the most significant crops consumed daily by individuals. Enhancing and biofortifying rice to augment its nutritional value is a promising strategy for improving public health and tackling the widespread issue of micronutrient deficiencies. This study primarily attempted to evaluate the developed Cas9-free edited lines grown hydroponically with a triple knockout of the negative metal sensor regulator uptake (OsHRZ1, OsHRZ2, and OsLCT1). This result shows that the Cas9-free edited lines’ performance was excellent, with no significant effect on the plant's agronomic performance or yield penalty due to multiplex knockout of genes, in addition to growing under cadmium stress conditions. The protein content of seeds was higher in the Cas9-free edited lines than the protein concentrations observed in the wild type (control/treated), where the protein concentration ranged from 17 to18 mg g−1 FW protein compared to the wild type (normal/treated) (7.24, 7.08) mg g−1 FW, respectively. The concentration varies based on the growth condition under deficient or sufficient Fe/Zn. Photosynthetic rates were increased in Cas9-free edited plants in comparison to wild rice plants, correlating with enhanced agronomic yield parameters and tolerance of cadmium conditions. Rice pollen grain viability and fertility were examined to check the effect of excess iron/zinc on pollen grain viability, fertility, and germination. The expression of genes closely linked to iron, zinc, and cadmium uptake and translocation in rice endosperm was studied. Developed rice lines hold a huge promise to overcome micronutrient malnutrition worldwide.
A novel embryonic axis-based regeneration system enables rapid shoot recovery, rooting, and biolistic gene delivery in cacao, substantially shortening the timeline for plant transformation.
Suzam L. da S. Pereira, Grazielle da M. Alcântara, Gláucia C. B. Silva et al.· Plant Cell Tissue and Organ...· 0 citations
