A review of recent advances in the structural diversity, evolutionary distribution, and functional specialization of DnaJ proteins across model plants and crops highlights DnaJ proteins as promising molecular targets for crop improvement and climate‐smart agriculture aimed at increasing productivity, stress tolerance, and postharvest performance under changing environmental conditions.
Muhammad Arif, H. M. Rehman, S. Bashir et al.· The Plant Genome· 0 citations
This paper introduces Caduceus, a family of MoE-enhanced foundation models built with a hierarchical pre-training paradigm to jointly integrate biological and natural language, and incorporates a multi-task instruction tuning phase, enabling robust protein parsing and natural language question answering.
Mingze Yin, Yiheng Zhu, Jialu Wu et al.· Proceedings of the 32nd ACM...· 0 citations
Hemoglobinopathies provide the first clinically validated delivery model for CRISPR therapeutics, and offers a donor-independent alternative to allogeneic hematopoietic stem-cell transplantation without graft rejection or graft-versus-host disease.
A pH-gated surface-mediated hydrogel patch for infection-responsive delivery of CRISPR-Cas9 ribonucleoprotein (RNP) complexes establishes a novel paradigm for localized, precision gene therapy and holds strong translational promise for the treatment of chronic inflammatory wounds.
Shuaishuai Feng, Yaping Li, Tingting Ye et al.· Materials Horizons· 0 citations
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The T-Editor platform enables rapid and efficient CRISPR-mediated gene editing for engineering TIL to enhance its therapeutic potency and FAM84B may represent a novel potential target for improving TIL-mediated antitumor activity.
Fenge Li, Xuejiao Ma, Yongming Xue et al.· Cancer Science· 0 citations
An optimized protocol balancing high transfection/transduction efficiency with minimized cytotoxicity was developed, supporting tissue-engineered IVD constructs and other CRISPR-based regenerative therapies for DDD.
Evan Davison Kotler, Sajjad Ashraf, J. Santerre et al.· Tissue Engineering. Part C,...· 0 citations
The genetics of hearing loss is transitioning from a diagnostic modality to an interventional one, with emphasis on emerging gene-based therapies, clinical trial design, regulatory and ethical considerations, and practical implications for otolaryngologists as biologic treatment enters clinical practice.
Emma Dunn, Spencer H Short, Ravi N Samy· Current Opinion in Otolaryng...· 0 citations
This optimized PE system substantially enhances PE efficiency in Cucurbit crops, providing an effective solution to common challenges such as low editing efficiency and limited heritability in these species.
Junya Wang, Ling Xiao, Tongxu Xin et al.· Journal of Integrative Plant...· 0 citations
This review summarizes recent progress in elucidating plant virus-vector molecular interactions and their potential use in innovative strategies for virus and vector control.
B. Bonning· Current Opinion in Virology· 0 citations
An RNA-guided bridge recombinase system is engineered through rational mutagenesis and AI-assisted directed evolution, enabling programmable chromosomal rearrangements in both plant and mammalian cells and achieving up to a 29.8-fold increase in activity.
Rui Gao, Jingjing Wei, Chao Sun et al.· Trends in Biotechnology· 0 citations
Compared with conventional homologous recombination, the CRISPR-Cas9 system substantially improved gene disruption efficiency, thereby overcoming a major limitation in the genetic manipulation of lichen-forming fungi.
Ze-Yi Wang, Niu-Niu Wang, Hai-Yu Zhang et al.· Journal of Fungi· 0 citations
This first-in-human study demonstrated the feasibility of an "off-the-shelf" base-edited CAR T cell approach and informs future multiantigen strategies against AML.
C. Georgiadis, Robert Chiesa, Hebatalla Rashed et al.· Science Translational Medici...· 0 citations
