Category
1,680 papers
This review aims to provide a brief historical overview of genetic counseling and its evolution, addressing the qualified professionals and clinical requirements necessary to obtain a diagnosis and post-test guidance across different stages of patients' lives. Recent advances in the understanding of genetic diseases an...
Genome editing, CRISPR screening, base and prime editing, regulatory-element assays, and inducible protein-depletion systems now allow increasingly precise and high-throughput characterization of coding and noncoding variants, enabling a transition in CHD research from descriptive genomics to integrated, multi-model ap...
Exosomes are an evolved sub-type of extracellular vesicles (EVs) that have gained popularity in recent years as a novel biological nanocarrier system for targeted precision therapy in cancer owing to their excellent biocompatibility, low immunogenicity, and high stability. While other artificial systems can only delive...
Drought and low nitrogen often co-occur in forests, yet their combined effects cannot be inferred reliably from single-stress studies. This review synthesizes physiological and molecular evidence for tree responses to combined drought and low nitrogen at four levels, namely stress perception, signal transduction, metab...
Reach audiences
Advertise in front of researchers, engineers, and readers.
Background/Objectives: Mitochondrial plasticity, reflected by the capacity of cancer cells to shift between oxidative phosphorylation and glycolytic metabolism in response to genetic alterations and changes in the tumor microenvironment, represents a key feature of melanoma progression. Sphingolipids contribute to the...
Ex vivo expansion is a fundamental yet challenging step in the manufacturing of adoptive cell therapies (ACT), as therapeutic success relies on generating enough functional immune cells while maintaining their phenotype, metabolic fitness, and persistence. This review provides a comprehensive overview of immunomodulato...
Dataset Description This repository contains the synthetic genomic workflow dataset generated and used for the experimental evaluation of the PRIVAGEN-SHIELD framework, “PRIVAGEN-SHIELD: Privacy-Preserving Genomic Anomaly Detection via Hierarchical Blockchain-Authenticated Merkle Trees and Local Differential Privacy.”...
Plant adaptation to drought, salinity, temperature extremes, pathogens, and herbivorous insects depends on coordinated hormone signalling, transcriptional control, and metabolic reprogramming. The jasmonic acid (JA) pathway is a major regulator of defence and the growth-defence trade-off, and the bHLH transcription fac...
Delivering therapeutic macromolecules to defined cell populations in vivo remains a central unsolved problem in biomedicine. Proteins, nucleic acids and viral vectors are cleared by phagocytes, degraded by enzymes, blocked by endothelial and interstitial barriers, and trapped in acidifying endolysosomes. Pre-existing i...
Gamma-aminobutyric acid (GABA) technology is a promising biotechnology method for enhancing stress tolerance and nutritional quality in agricultural plants. Although tomato (Solanum lycopersicum) is a major vegetable crop consumed worldwide and is rich in vitamins, minerals, and antioxidants, tomato fruits naturally co...
The CRISPR-Cas9 system's gene-editing fidelity relies on the HNH nuclease domain's ability to hydrolyze DNA via metal-ion catalysis. While IscB-ωRNA variants offer advantages for viral delivery due to their small size, their editing efficiency is much lower than Cas9. The understanding of how HNH-domain dynamics and me...
Genie 4: our new world model unlocking unprecedented realism in real-time simulation.
Generative AI
General Science
A Blog post by NVIDIA on Hugging Face
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
General Science
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
