gene editing

Therapeutic reprogramming of natural killer cells for solid tumors: expanding frontiers into rare and ultra-rare malignancies

Progress in NK cell therapy across solid tumors provides a framework for extending increasingly adaptable and scalable immunotherapeutic platforms to rare and ultra-rare malignancies, with the potential to expand treatment opportunities for patient populations that have historically had limited therapeutic options.

Protein language models predict artemisinin partial resistance and prioritize genetic modifiers in Plasmodium falciparum

Translational Cardiology in Genetic Cardiomyopathies

Translational cardiology applied to genetic cardiomyopathies is a rapidly evolving field that bridges molecular research and clinical practice through a “bench-to-bedside and back” paradigm. Hereditary cardiomyopathies, once classified primarily based on clinical phenotype, are now increasingly understood at the molecu...

Biotechnological Advances and Multi‐Omics Insights for Fruit Quality, Postharvest Biology, and Genetic Improvement in Litchi ( Litchi chinensis Sonn.)

This review critically synthesizes current progress in litchi biotechnology, encompassing chromosome‐scale genome assembly, molecular marker systems, SNP resources, and functional genomics studies that have identified major regulatory genes and transcriptional networks associated with flowering, pigmentation, senescenc...

Bactomics HybAs v8.4-lite

This release is a major workflow upgrade from the legacy 8.4-lite Snakefile to a batch-capable, provenance-aware, benchmarked, validation-enabled, report-ready HybAs implementation. The new workflow preserves the core hybrid assembly logic while substantially improving execution control, reproducibility, taxonomic deci...

Bactomics HybAs v8.4-lite

This release is a major workflow upgrade from the legacy 8.4-lite Snakefile to a batch-capable, provenance-aware, benchmarked, validation-enabled, report-ready HybAs implementation. The new workflow preserves the core hybrid assembly logic while substantially improving execution control, reproducibility, taxonomic deci...

Morphological and biochemical evaluation of tolerance to water deficit identifies SlCLE9 as a novel regulator of drought stress

A screening to evaluate the responses to water deficit before the flowering stage uncovered new potential trait donors for breeding against drought stress and describes a novel role for SlCLE9 in drought tolerance in tomato.

Arrhythmogenic Cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM) is an inherited myocardial disease characterized by progressive fibro-fatty replacement of the ventricular myocardium, predisposing to ventricular arrhthmias, heart failure, and sudden cardiac death. Historically described as arrhythmogenic right ventricular cardiomyopathy (ARVC), AC...

CanProTarget

A residue-resolved prioritization platform for covalent cancer drug discovery. CanProTarget integrates cancer gene dependencies, small-molecule covalent ligand engagement measured by chemoproteomics, and base-editing evidence for individual cysteines, keeping each layer at the resolution it is measured at.

EDITING OUT CARDIOVASCULAR RISK: A NARRATIVE REVIEW OF GENE-EDITING APPROACHES TO PCSK9

Early clinical and preclinical evidence supports the feasibility of PCSK9 gene editing, and compares CRISPR-Cas9 nuclease knockout, base editing, and epigenetic silencing with established antibody and siRNA classes, focusing on efficacy, durability, and safety.

Does adjusting for tumor proliferation bias prognostic gene expression estimates? Preregistered analysis code, decision rules and results

R analysis code, preregistered decision rules, result files, run logs and figures for a study of what omitting tumor proliferation does to prognostic gene expression estimates. For every expressed gene in a cohort, two Cox models are fitted for overall survival, one adjusted for age, sex and stage and one that adds a s...

Supporting data for “Comparative Genomics in the genus Caenorhabditis and the Discovery of a Novel Toxin-Antidote System in C. elegans”

This dataset accompanies the thesis “Comparative Genomics in the genus Caenorhabditis and the Discovery of a Novel Toxin-Antidote System in C. elegans.” It contains 37 files documenting the comparative genomic analyses and experimental work presented in the thesis. Main and supplementary figures cover genetic mapping,...