The experimental developments that preceded the discovery of induced pluripotency are discussed, major advances achieved over the following two decades are summarized, and the directions in which the field is likely to develop further are considered.
M. А. Lagarkova, A. N. Tomilin· Регенерация органов и тканей· 0 citations
A modular, doxycycline-inducible vector system that integrates gene overexpression, shRNA-mediated knockdown, and CRISPR/Cas9-mediated regulation within a single, lentivirus-compatible system that expands the experimental repertoire for dynamic, multigene interrogation in complex systems.
Seher Alam, Daria Matvienko, Johan Boström et al.· bioRxiv· 0 citations
Two novel monoclonal HLA genes homo/heterozygous knockout hESC lines are presented, along with their multi-omics landscapes, pluripotency and immunogenicity, which exhibit crucial application potential and reference value in the development of hypoimmunogenic hESCs for their universal clinical use.
Ling-Huo Zhang, Bo Cai, Xiao-Xiao Li et al.· International Immunopharmaco...· 0 citations
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The prevalence and resistance mechanisms of S. aureus in clinical, food, and environmental contexts are investigated, promising alternative therapies are explored, and the urgent need for global antimicrobial stewardship (AMS) and sustainable intervention strategies are emphasized.
Kiandokht Babolhavaeji, Sima Kazemi, Tahereh Etesamifard et al.· International Journal of Mic...· 0 citations
The context-dependent roles of iron, copper, zinc, aluminum, and manganese in the pathogenesis of AD are reviewed, with a particular focus on their bidirectional interactions with classic AD pathology.
Jiao-Yan Yang, Fan Lou, Wei Sun et al.· Pharmacological Research· 0 citations
A protocol for delivering CRISPR-Cas9 or prime editors into PDAC cell lines using retrovirus-derived engineered virus-like particles (eVLPs) and adapts readily to other genomic sites.
Chloe Timmins-Young, M. Cordani, E. Giovannetti et al.· STAR Protocols· 0 citations
Developing climate-resilient crops is critical for ensuring global food security, yet agricultural productivity is frequently constrained by the trade-off between stress tolerance and growth. This challenge is particularly acute in allohexaploid wheat, a staple crop susceptible to abiotic stresses, underscoring the dem...
Xiao-Min Si, Yong-Hui Yan, Sheng-Long Bai et al.· New Phytologist· 0 citations
Hidden hunger (micronutrient deficiency) contributes majorly for poor mental and physical health for every age group and gender across the world. Here we integrated rice grain ionome with high resolution tissue and developmental stage specific transcriptomic to elucidate the molecular basis of Fe/Zn accumulation in two...
The rapidly global deployment of COVID-19 mRNA-LNP vaccines established the clinical feasibility of combining RNA medicine with LNP delivery systems, transforming a long-standing experimental concept into a scalable therapeutic modality, previously considered impossible. Currently, the value of mRNA-LNPs has been expan...
Yuan Wang, You Ge, Yu Chen et al.· Journal of Hematology & Onco...· 0 citations
This review focuses primarily on the current state of CRISPR-based epigenome editing systems, including acetyltransferases, demethylases, DNA methyltransferases, and deacetylases, and their applications in crop improvement research and critically evaluates their mechanisms in rewriting epigenetic regulatory information...
Genetically modified Plasmodium falciparum parasites expressing transgenes such as fluorescent markers are crucial tools for malaria research. However, current reporter lines often rely on integrated transgene constructs that disrupt the coding sequence of a native gene, potentially affecting progression in the life cy...
Laura J. Akkerman, Silvia Tassan-Lugrezin, Ezra T. Bekkering et al.· bioRxiv· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
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