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633 papers
dFTN ferritin domains are described, which expand the range of known ferritin family proteins and provide insight into Asgard archaea iron metabolism.
It is proposed that HP6/Umbrea acts like a plasticizer, a molecular softener that could make otherwise silenced heterochromatic genes leakier and thus potentially act as a rheostat for leaky transcription.
LemonCatcher is created, a protein superglue that spontaneously forms an amide bond to the LemonTag peptide under these harsh acidic and cold quench conditions, even at -20 °C, and SelQueX makes possible selective characterization of protein structural dynamics within the complex cellular milieu.
How solid-phase peptide synthesis, genetically encoded libraries, and high-throughput selection and screening enable systematic exploration of vast, noncanonical landscapes largely inaccessible to traditional engineering is discussed.
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This study highlights a new role for agmatine in bacterial polyamine biosynthesis, which also includes the N1-aminopropylagmatine and carboxyaminopropylagmatine pathways for spermidine production.
Treating primary cardiomyopathy as a 'organelle network disease', in which organelles constitute a dynamic, interdependent ecosystem, provides a useful integrative paradigm for comprehending the causes.
Sustaining daily ultrarunning for more than 1 year induces substantial skeletal muscle remodelling, including reduced muscle size, impaired contractile function and mitochondrial maladaptations, despite largely preserved endocrine and haematological stability.
New insights into the precision treatment of endometrial cancer are provided by developing engineered, multifunctional, exosome-based therapeutic drugs that combine mechanism precision and translational feasibility in tumor treatment.
Findings indicate that PEGylation reduces ApoE association primarily through steric exclusion and highlight PEGylation as a useful strategy for modulating nanoparticle biodistribution.
Reduced plasma DSP levels reflect a susceptibility to early-onset ICH and represents a promising adjunctive biomarker for prognostic risk stratification, particularly in young patients with mild-to-moderate disease severity.
This case illustrates an unusual manifestation of severe jaw pain of unknown origin that was determined to be caused by VOC of the mandible, highlighting the need for dentists to understand SCA pathophysiology and their integral role in the diagnosis of atypical facial pain in patients with SCA.
A scalable, open-source, deep-learning approach to quantify NFT burden in digital whole slide images (WSIs) of post-mortem human brain tissue and openly releases this multi-institution deep-learning pipeline to provide detailed NFT spatial distribution and morphology analysis capability at a scale otherwise infeasible by manual assessment.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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