Jul 2026· Nanomedicine: Nanotechnology, Biology and Medicine· pp.
102998
· 0 citations· 60 references
Medicine
TL;DR
Electrospun nanofibers of polyacrylonitrile loaded with apigenin and naringenin as an effective strategy to promote diabetic wound healing have been developed and revealed that the nanofibers accelerate wound healing and lead to wound closure of 96.23% on day 14 along with enhanced epithelialization, collagen synthesis, and inhibition of NF-κB and TNF-α expression.
Abstract
Diabetic wound is marked by chronic inflammation, oxidative stress, and poor tissue regeneration, requiring novel wound dressings. In this work, electrospun nanofibers of polyacrylonitrile (PAN) loaded with apigenin and naringenin as an effective strategy to promote diabetic wound healing have been developed. Characterization of the optimized nanofibers was performed using physicochemical, mechanical, surface, and biological methods, after which the wound healing activity of the nanofibers in a diabetic wound model induced by streptozotocin and nicotinamide was evaluated. The prepared nanofibers demonstrated a smooth structure, high content of drugs (91.2 ± 3.4% apigenin, 87.6 ± 2.8% naringenin), good mechanical stability, increased hydrophilicity (58.4 ± 2.1°), biphasic drug release pattern, high biocompatibility, and antioxidant properties. In vivo experiments revealed that the nanofibers accelerate wound healing and lead to wound closure of 96.47 ± 3.23% on day 14 along with enhanced epithelialization, collagen synthesis, and inhibition of NF-κB and TNF-α expression.
Through rational core-shell design, this study integrates antioxidant and immunomodulatory functions within a single coaxially electrospun scaffold, offering a clinically translatable strategy for chronic diabetic wound repair and the comprehensive structural and functional reconstruction of skin tissue.
Kexin Feng, Xiaoyu Wang, Zichao Cai et al.· Journal of materials chemist...· 0 citations
The findings suggest that nanofiber wound dressings formulated with nanoscale materials represent a promising and effective alternative to conventional wound dressings, particularly for the therapeutic management of injuries associated with chemical, biological, radiological, and nuclear(CBRN) incidents.
N. Tufan, Halis Uğuz, S. Karakurt· Polymer Bulletin· 0 citations
Multifunctional dressings have emerged as a promising approach for treating chronic wounds. a bionic, multifunctional hydrogel nanofiber dual-layered dressing (H-NF-DLD) were developed. The dressing was electrostatically spun with chestnut shell polyphenols (CSPs) and levofloxacin (LEV) loaded onto a zein nanofiber membrane (NFM), which was laminated with a sodium alginate and carboxymethyl chitosan crosslinked hydrogel layer to form a "sandwich" structure. The combination of CSPs and LEV resulted in significant responsiveness of the NFM in terms of stability, antioxidant properties, natural degradation, limited cytotoxicity, and hemolysis. The antimicrobial activity of the NFM against Staphylococcus aureus and Pseudomonas aeruginosa was >60%, higher than that of the LEV-only dressing (53%-56%). The wound healing time using the mixed CSP and LEV dressing (CSP-LEV) was advanced by 7 days compared with that in diabetic rats. The dressing was permeable and superior to commercial LEV alone. The healing effects of the dressing were related to its antioxidant, anti-inflammatory, bacteriostatic, and growth-promoting properties. This study provides an efficient therapeutic strategy for wounds in type 2 diabetes. The developed dressing is expected to reduce the need for antibiotics, lower healthcare costs, and promote the use of chestnut by-products.
Yue Li, Jing Guo, Xuli Wang et al.· International Journal of Bio...· 0 citations
BACKGROUND
Diabetic burn wounds are challenging comorbid conditions to heal, hence shikonin, a traditional phytoconstituent was nanofabricated in the present study. This study is the continuation of our previously published work including shikonin-loaded nanoemulsion against wound pathogens.
OBJECTIVE
Current work aims to further prepare electrospun scaffolds to promote wounded skin regeneration.
METHODS
Studies including DLS, ATR, XRD, SEM were used to assess pharmaceutical stability of system. In vivo model, western blotting (protein expression of MMP-9), soluble collagen and MMP-9 ELISA kit assays, molecular docking and simulations studies were used to evaluate pharmacodynamic stability.
RESULTS
The developed scaffolds exhibited chemical stability, improved aqueous solubility with average diameter of 235 ± 23 nm. The wound area got remarkably decreased (4.923 ± 0.935%) with high collagen content (88.515 ± 2.23%) and lower MMP-9 content (6.726 ± 0.820%) than the comparable groups.
CONCLUSION
The present study displayed the developed system with remarkable wound healing potential.
Kirandeep Kaur, A. Monga, Anshula Mehra et al.· Journal of Microencapsulatio...· 0 citations
An integrated approach combining network pharmacology, molecular docking, molecular dynamics simulations, and experimental validation revealed that the therapeutic efficacy of sustained local α-MG delivery involves the modulation of the PPAR-γ pathway.
Yuan Ma, Xu Liu, Zhewen Deng et al.· International Journal of Bio...· 0 citations
The synergistic bioactive effects of CH and GO, along with the ECM-mimicking nanofibrous architecture of the electrospun dressing, demonstrate its potential as a promising candidate for the treatment of chronic wounds.
Alireza Sadeghi-Avalshahr, Simin Nazarnezhad, Negar Namaei-Ghasemnia et al.· Journal of Biomaterials Scie...· 0 citations