Aug 2026· International Journal of Analysis and Applications· 0 citations· 18 references
TL;DR
This study develops an SEIR model for TB transmission, taking into account the early diagnosed latent infections, and shows that combined strategy which involve all interventions reduce the total cost, while transmission reduction only strategy gives the greatest reduction in infected individuals.
Abstract
Tuberculosis (TB) remains one of the most dangerous infections disease and a major public health problem. This study develops an SEIR model for TB transmission, taking into account the early diagnosed latent infections. The model is used to derive the basic reproductive number \(\mathcal{R}_0\), study equilibrium points, and identify the most influential parameters through sensitivity analysis on \(\mathcal{R}_0\). An optimal control is formulated using four interventions: transmission reduction, early diagnosed latent TB, treatment, and vaccination. Different strategies are compared using infection averted, total cost, the average cost effectiveness ratio (ACER) and incremental cost effectiveness ratio (ICER). The results show that combined strategy which involve all interventions reduce the total cost, while transmission reduction only strategy gives the greatest reduction in infected individuals.
An age-structured mathematical model for HIV/AIDS transmission dynamics in Nigeria has been formulated and analyzed, indicating persistent disease transmission without interventions and cost-effectiveness analysis revealed that adult prevention contributes approximately 32% of total infection reduction.
C. Agha, Henry O. Adagba, S. Aloke et al.· World Journal of Advanced Re...· 0 citations
Cost-effectiveness analysis using infection averted ratio (IAR), average cost-effectiveness ratio (ACER), and incremental cost-effectiveness ratio (ICER) reveals that the combined implementation of all six control measures (Strategy 9) is most cost-effective, averting 9,200 infections (35.38% reduction) at an ACER of 3...
Francis Agono, G. Acheneje, B. C. Agbata et al.· European Journal of Statisti...· 0 citations
Tuberculosis (TB) is considered a severe disease and remains a serious public health problem in developing regions, especially in Khyber Pakhtunkhwa (KPK), Pakistan, where the failure to timely diagnose the disease, poor access to healthcare, poverty, and treatment interruptions significantly contribute to the disease'...
Abidah Amir, Awais Ahmad, S. Zeb et al.· African Scientific Reports· 0 citations
A deterministic SEIR-TB compartmental model tailored to Nairobi's specific epidemiological setting is developed to estimate R₀ and determine the stability of equilibrium states, and the comparative effectiveness of single and combined TB control interventions through numerical simulation is evaluated.
Background. Management of the multidrug-resistant tuberculosis epidemic requires resource optimization under conditions of high dimensionality and model nonlinearity. The purpose of the study is to develop a methodology for analyzing optimal control scenarios for a multi-compartmental tuberculosis epidemiology model to...
O. V. Korchevskaya· University proceedings Volga...· 0 citations
Malaria remains an important cause of morbidity in young children in western Kenya, where intervention effectiveness depends not only on nominal coverage but also on biological efficacy, adherence, vector behaviour, insecticide susceptibility, and local transmission intensity. This study develops a deterministic human–...
Opicho Dominic Simiyu, B. Kwach, R. Nyukuri· Asian Research Journal of Ma...· 0 citations
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