Aug 2026· Cell Metabolism· Vol 38, pp. 1751-1753· 0 citations· 10 references
Medicine
TL;DR
This work proposes that protein restriction extends lifespan across species and engages many hallmarks of aging as components of a single coordinated physiological state, with enhanced longevity emerging from this adaptive response.
Abstract
Protein restriction extends lifespan across species and engages many hallmarks of aging. We propose that these diverse responses can be understood as components of a single coordinated physiological state. This response involves both cellular nutrient sensing and endocrine and neural coordination, with enhanced longevity emerging from this adaptive response.
The data chart a comprehensive landscape of protein aggregation during vertebrate aging and identify strong, tissue-specific associations with dysfunction and disease.
Yi-Wen R. Chen, I. Singh, Ben E. Machado et al.· 0 citations
Hypoxia is not simply harmful or protective. Recent studies suggest that hypoxia-inducible factor 1-alpha (HIF-1α) acts as a time- and context-sensitive regulator of tissue-state transitions. We propose that transient HIF-1α activity enables regenerative entry, whereas persistent or unresolved signalling promotes malad...
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How cells adapt their membranes to prolonged stress is poorly understood. Williams et al. show that chronic hyperosmotic stress triggers lipid droplet accumulation and a shift toward phosphatidylcholine in budding yeast. Triacylglycerol synthesis supports adaptive changes in membrane properties, while elevated phosphat...
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