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Proximity labeling puts ZFP36L1 as central hub for posttranscriptional regulation networks in T cells

Anouk P. Jurgens Branka Popović Floris P. J. van Alphen M. Steinmetz Leyma Wardak Antonia Bradarić Sander Engels C. van der Zwaan M. van den Biggelaar Arie J. Hoogendijk Julien Béthune M. Wolkers
Sep 2026 · Life Science Alliance · Vol 9 · 0 citations · 112 references
Medicine

TL;DR

Using proximity labeling, a comprehensive interactome map of the RBP ZFP36L1 is presented, demonstrating the versatility of interactions and their possible functioning during T-cell activation.

Abstract

RNA binding proteins (RBPs) are key regulators of controlling the proteome remodeling during T-cell activation. Using proximity labeling, we present a comprehensive interactome map of the RBP ZFP36L1, demonstrating the versatility of interactions and their possible functioning during T-cell activation.

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