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Unraveling the roles of DKK1 and S100P in pancreatic ductal adenocarcinoma: Insights from machine learning, single-cell/spatial transcriptomics, and functional validation

Yanzhao Mao Yu-Qi Zhang Yu-Peng Zhang Dongwei Lin Yue-Lin Song Xiaojiang Niu Peihao Xv Yuliang Wang Zhi-Gang Wei
Jul 2026 · Translational Oncology · Vol 72, pp. 102949 · 0 citations · 37 references
Medicine

TL;DR

Functional assays confirmed that DKK1 and S100P significantly promote PDAC cell proliferation and migration in the tumor microenvironment.

Abstract

Highlights • Multi-omics integration and machine learning identified DKK1 and S100Pas PDAC prognostic genes.• scRNA-seq and spatial transcriptomics revealed distinct expression patterns in the tumor microenvironment.• Functional assays confirmed that DKK1 and S100P significantly promote PDAC cell proliferation and migration.

DOI PubMed Semantic Scholar
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