Sep 2026· Diabetes, obesity and metabolism· Vol 28, pp. 10780 - 10794· 0 citations· 45 references
Medicine
TL;DR
The contributions of clinical characteristics and genetic predisposition as measured through partitioned polygenic risk scores (pPRS) to variation in glycemic response to glucose‐lowering therapies are quantified.
Abstract
Treatment response in type 2 diabetes (T2D) varies widely among individuals. This study aimed to quantify the contributions of clinical characteristics and genetic predisposition as measured through partitioned polygenic risk scores (pPRS) to variation in glycemic response to glucose‐lowering therapies.
Pathway‐specific polygenic risk scores (psPRS) provide insights into the heterogeneity of type 2 diabetes. We aim to study whether psPRS for beta cell dysfunction, obesity and metabolic syndrome associate with risk of hyperglycaemic progression in Southeast Asian patients with type 2 diabetes.
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We evaluated overall and sex‐specific performance of established diabetes risk models for predicting incident dysglycaemia in African and European populations.
M. F. Smidt, Patrik Wennberg, Hannah Maike Albers et al.· Diabetes, obesity and metabo...· 0 citations
This network Mendelian randomisation study delineates protein-mediated pathways linking cluster-stratified T2D genetic predisposition to cardiovascular risk, which can inform preventive strategies by stratifying individuals based on distinct biological pathways represented by these genetic clusters.
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To estimate the proportion of older patients with type 2 diabetes (T2D) and HbA1c above or below goal at provider level and explore factors associated with patients being above or below goal.
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The metabolic phenotypes were explored in a primary care T2DM cohort, supporting their reproducibility across clinical settings and vitamin D status varied by phenotype severity, with more severe phenotypes more likely to exhibit insufficiency.
L. V. Pires, Matheus Menezes-Santos, Andréa Costa Goes et al.· Diabetes, obesity and metabo...· 0 citations
To examine whether insulin resistance (IR), assessed by cumulative triglyceride–glucose (TyG)‐derived indices and change patterns, stratifies incident cardiovascular disease (CVD) risk after glycaemic transition in adults with prediabetes.
Hui-Qiang Cai, Yi Fu, Fang-Ge Zhu et al.· Diabetes, obesity and metabo...· 0 citations
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