The Triglyceride‐Glucose (TyG) Index and Incident Diabetes and Cardiovascular Events in People Living With HIV‐1 Infection. A 14‐Year Observational Cohort Study
Sep 2026· European Journal of Clinical Investigation· Vol 56· 0 citations· 21 references
Medicine
TL;DR
The triglyceride‐glucose (TyG) index has shown predictive value for Type 2 diabetes mellitus (T2DM) and cardiovascular events (CVEs) in the general population, but its utility in PWH remains unclear.
Abstract
People living with HIV (PWH) are at increased risk for metabolic and cardiovascular diseases. However, there is no structured prevention strategy for these subjects. The triglyceride‐glucose (TyG) index has shown predictive value for Type 2 diabetes mellitus (T2DM) and cardiovascular events (CVEs) in the general population, but its utility in PWH remains unclear.
The atherogenic index of plasma (AIP) is a lipid‐based indicator of cardiometabolic risk. We examined whether AIP is associated with prevalent type 2 diabetes mellitus (T2DM) and fasting blood sugar (FBS) in patients with premature coronary artery disease (PCAD) and explored whether this association differed across Ira...
Raza Amani-Beni, G. Dabaghi, N. Mohammadifard et al.· Endocrinology, Diabetes & Me...· 0 citations
Sarcopenia is a prevalent and disabling complication of Type 2 diabetes mellitus (T2DM), which significantly elevates the risks of falls, fractures, institutionalization, and all‐cause mortality. Lipotoxicity mediated by circulating free fatty acids (FFA) is crucial in the pathogenesis of diabetes‐related sarcopenia, b...
Qian Yu, Min Ding, Hong-Yan Yu et al.· Geriatrics & Gerontology Int...· 0 citations
Background
The C-reactive protein-triglyceride glucose index (CTI) has recently been introduced as a novel composite biomarker that integrates inflammation and insulin resistance. However, the association between CTI and incident cardiovascular disease (CVD) in individuals with hypertension remains unclear.
Methods
W...
Yin Wang, Jie Luo, Zhao-Fu Tan et al.· Endocrinology and Metabolism· 0 citations
Depression and long‐term HbA1c variability are associated with adverse outcomes in type‐2 diabetes (T2D), which may be related to suboptimal self‐management practices and health‐related quality of life (HRQoL).
K. Wong, E. W. Chow, E. Lau et al.· Diabetes/Metabolism Research...· 0 citations
In people without HIV, raised coronary artery calcium scores (CACS) are linked to increased cardiovascular risk. HIV is associated with elevated CACS, but risk factors beyond smoking and diabetes are not well established. Data on 779 individuals with HIV who underwent a CACS scans (median age 55) were collected. CACS b...
Maithili Varadarajan, Ruth Byrne, Abethale Al-Hussaini et al.· AIDS (London)· 0 citations
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